Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 16.1, Problem 1EQ
Summary Introduction
To describe: The known effects of progesterone on oocytes prior to the study conducted by Masui and Markert.
Introduction: Yoshio Masui and Clement Markert studied the effect of progesterone on frog oocytes. Oocytes are the cells that on maturity turn into egg cells. Prior to their studies, a group of researchers has already identified that frog oocytes turn dormant in the G2 phase of cell cycle. Progesterone is the hormone produced by female frogs during mating season.
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Let's say that an experiment had no disruption to kinetochores and you are able to inactivate the CDC 14 phosphatase, which acts to remove phosphate groups from substrates that were previously phosphorylated by active MPF. What effect, if any, would this have on (i) the duration (length) of the mitotic phase, (ii) the timing of cyclin B’s appearance or disappearance, and (iii) the period of time for which MPF is active? Briefly explain your reasoning
The retinoblastoma protein (RB) suppresses human cell division by
arresting cells in the G₁ phase of the cell cycle and preventing
progression to the next phase. It accomplishes this task by binding
to another protein, E2F, a transcription factor needed for further
progression through the cell cycle. Normal progression through the
cell cycle is accomplished when cyclin-dependent kinases (CDKs)
phosphorylate RB, preventing its binding to E2F.
Many viruses can induce abnormal exit from G, using viral proteins
that bind to RB at a motif at the N-terminal called LXCXE. An
example is the E7 papilloma protein, which causes the excessive
proliferation of cells in warts.
The site at which LXCXE proteins bind is called the pocket domain
and is highly conserved on RB and related proteins in plants and
animals. The configuration of the pocket domain is well established.
Mutant experimental RB proteins are available with alterations in the
conserved amino acids of the pocket domain.
A simple…
The retinoblastoma protein (RB) suppresses human cell division by
arresting cells in the G₁ phase of the cell cycle and preventing
progression to the next phase. It accomplishes this task by binding
to another protein, E2F, a transcription factor needed for further
progression through the cell cycle. Normal progression through the
cell cycle is accomplished when cyclin-dependent kinases (CDKs)
phosphorylate RB, preventing its binding to E2F.
Many viruses can induce abnormal exit from G, using viral proteins
that bind to RB at a motif at the N-terminal called LXCXE. An
example is the E7 papilloma protein, which causes the excessive
proliferation of cells in warts.
The site at which LXCXE proteins bind is called the pocket domain
and is highly conserved on RB and related proteins in plants and
animals. The configuration of the pocket domain is well established.
Mutant experimental RB proteins are available with alterations in the
conserved amino acids of the pocket domain.
A simple…
Chapter 16 Solutions
Biology
Ch. 16.1 - Researchers usually treat cells with drugs that...Ch. 16.1 - Which phases make up interphase?Ch. 16.1 - Prob. 1CSCh. 16.1 - Prob. 1EQCh. 16.1 - The Eukaryotic Cell Cycle CoreSKILL What...Ch. 16.1 - Prob. 3EQCh. 16.2 - Prob. 1CCCh. 16.2 - Mitotic Cell Division Concept Check: What are the...Ch. 16.3 - Core Skill: Modeling The goal of this modeling...Ch. 16.4 - Sexual Reproduction Concept Check: What is the...
Ch. 16.5 - Variation in Chromosome Structure and Number...Ch. 16 - Prob. 1TYCh. 16 - Prob. 2TYCh. 16 - Prob. 3TYCh. 16 - Prob. 4TYCh. 16 - Prob. 5TYCh. 16 - Which of the following is not an event of anaphase...Ch. 16 - Prob. 7TYCh. 16 - Which of the following statements accurately...Ch. 16 - Prob. 9TYCh. 16 - Aneuploidy may be the result of a. duplication of...Ch. 16 - Prob. 1CQCh. 16 - Prob. 2CQCh. 16 - Prob. 3CQCh. 16 - Prob. 1COQCh. 16 - A diploid eukaryotic cell has 10 chromosomes (5...
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