A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in the figure attached. Discuss and interpret this model. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene. NATIONAL CENTERCASETUDI TEAChING IN SCIENCEXX XMitoticS PhaseReciprocalCrossoverMut RB1Heterozygousat RB1 LocusDuplicatedChromosomesresult from S phaseMitosis CouldProduce EitherCombination ofDaughter CellsDODOBoth Daughter Cells RetainHeterozygous Status at RB1 LocusLOH toLOH toHomozygousHomozygousWTMUTFigure 1. LOH through mitotic reciprocal crossing over. Adapted from The Biology of Cancer, 2nd ed.2014. Weinberg RA. Garland Science, Taylor & Francis Group, LLC.No Ability toRegulateProliferation

Mitosis is a type of cell division in which the daughter cells formed have same ploidy level as…

Answered: A second hit might also occur through…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in the figure attached. Discuss and interpret this model. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene.

NATIONAL CENTER
CASE
TUDI TEAChING IN SCIENCE
X
X X
Mitotic
S Phase
Reciprocal
Crossover
Mut RB1
Heterozygous
at RB1 Locus
Duplicated
Chromosomes
result from S phase
Mitosis Could
Produce Either
Combination of
Daughter Cells
DO
DO
Both Daughter Cells Retain
Heterozygous Status at RB1 Locus
LOH to
LOH to
Homozygous
Homozygous
WT
MUT
Figure 1. LOH through mitotic reciprocal crossing over. Adapted from The Biology of Cancer, 2nd ed.
2014. Weinberg RA. Garland Science, Taylor & Francis Group, LLC.
No Ability to
Regulate
Proliferation

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