A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in the figure attached. Discuss and interpret this model. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene.

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A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in the figure attached. Discuss and interpret this model. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene.

NATIONAL CENTER
CASE
TUDI TEAChING IN SCIENCE
X
X X
Mitotic
S Phase
Reciprocal
Crossover
Mut RB1
Heterozygous
at RB1 Locus
Duplicated
Chromosomes
result from S phase
Mitosis Could
Produce Either
Combination of
Daughter Cells
DO
DO
Both Daughter Cells Retain
Heterozygous Status at RB1 Locus
LOH to
LOH to
Homozygous
Homozygous
WT
MUT
Figure 1. LOH through mitotic reciprocal crossing over. Adapted from The Biology of Cancer, 2nd ed.
2014. Weinberg RA. Garland Science, Taylor & Francis Group, LLC.
No Ability to
Regulate
Proliferation
Transcribed Image Text:NATIONAL CENTER CASE TUDI TEAChING IN SCIENCE X X X Mitotic S Phase Reciprocal Crossover Mut RB1 Heterozygous at RB1 Locus Duplicated Chromosomes result from S phase Mitosis Could Produce Either Combination of Daughter Cells DO DO Both Daughter Cells Retain Heterozygous Status at RB1 Locus LOH to LOH to Homozygous Homozygous WT MUT Figure 1. LOH through mitotic reciprocal crossing over. Adapted from The Biology of Cancer, 2nd ed. 2014. Weinberg RA. Garland Science, Taylor & Francis Group, LLC. No Ability to Regulate Proliferation
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