EP CAMPBELL BIO.IN FOCUS AP-MOD.MASTER.
EP CAMPBELL BIO.IN FOCUS AP-MOD.MASTER.
3rd Edition
ISBN: 9780137453092
Author: Urry
Publisher: SAVVAS L
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Chapter 15.3, Problem 2CC

MAKE CONNECTIONS Inactivation of one of the X chromosomes in female mammals results in a Barr body (see Concept 12.2). Suggest a model for how the noncoding RNA described in Concept 12.2 (XIST RNA) functions to cause Barr body formation.

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MAKE CONNECTIONS Inactivation of one of the Xchromosomes in female mammals involves lncRNA calledXIST RNA, mentioned in this section and in Concept 15.2.Describe transcription and binding of XIST RNA, thensuggest a model for how it initiates Barr body formation.
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Dosage compensation is critical for organisms with sex chromosomes to equilibrate gene expression. The role of long non-coding RNAs has been shown to play an important role in affecting the decision to carry out X chromosome inactivation during dosage compensation in mammals. Q9a) How can a long non-coding RNA affect the decision to keep an X-chromosome active in female mammals?  Q9b) How can a long non-coding RNA initiate the steps to silence the chromosome to be inactivated?  Q9c) Explain which long non-coding RNA is responsible for the various steps to silence the inactive X and describe how its function leads to changes in the chromatin that are incompatible with active transcription off the inactive X
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