Biology: The Dynamic Science
Biology: The Dynamic Science
4th Edition
ISBN: 9781337246422
Author: Peter J. Russell; Paul E. Hertz; Beverly McMillan
Publisher: Cengage Learning US
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Chapter 15, Problem 6TYK
Summary Introduction

Introduction:

The protein after synthesis is targeted to a location where it performs a specific function. A sequence of 13–15 amino acids called signal sequence directs the proteins to its location.

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Eukaryotic cells manufacture cytoskeletal proteins, which help to maintain cell shape and function. What would you predict about these proteins?   A. They initially contain signal sequences that allow their entrance into the endoplasmic reticulum   B. They are glycosylated in the Golgi apparatus   C. They travel to the nucleus in a transport vesicle with a specific signal   D. They are manufactured on free ribosomes in the cytoplasm
Ribosomes in the cytoplasm (cytosol) capture mRNA that can be translated into an enzyme (in this case a protease) to the lysosome. a) Describe what happens from the time the enzyme (protease) begins to form in the cytoplasm until it end up in the lysosome and explain how the enzyme is transported to the lysosome.
Much of procollagen formation occurs in the endoplasmic reticulum and Golgi apparatus which requires signal peptide. All of the following statements about targeting a protein for the ER are true except     A. signal peptide usually has a positively charged N-terminus and a stretch of hydrophobic amino acids. B. signal peptide emerging from a free ribosome binds signal recognition particle (SRP). C. signal peptide is usually cleaved from the protein before the protein is inserted into the ER membrane. D. docking protein is actually an SRP receptor and serves to bind the SRP to the ER. E. SRP and docking protein do not enter the ER lumen but are recycled.
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