Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 14, Problem 29RQ
Summary Introduction

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The series of reactions thatshow the role of pyridoxal phosphate in the reaction of alanine and α-ketoglutarate.

Introduction:

Transamination can be characterized by the transfer of α-amino groups from α-amino acid to α-keto acid. This reaction is catalyzed by aminotransferase enzyme, which is also called transaminase. In this reaction, the keto acid acts as the acceptor while the amino acid acts as the donor of amino group. This results in the formation of a new amino acid and a new keto acid. Such reactions require a coenzyme called PLP (pyridoxal-5’-phosphate). This enzyme is derived from a vitamin B6, pyridoxine.

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