Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 13, Problem 1Q
How could you use paclitaxel, which makes MTs less likely than normal to depolymerize, to study whether the completion of mitosis requires disassembly of MTs?
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Students have asked these similar questions
Suppose cells in an experiment had been labeled with green fluorescent tubulin.
At the onset of Anaphase B, you use your laser to bleach a stripe across all of the
microtubules on one side of the spindle as shown by the dashed line. This does
not hurt the function of the microtubules in any way, but the bleached,
nonfluorescent subunits in the microtubules now serve to mark a fixed location
relative to the (+) and (-) ends.
pl. membr.
spindle
A. Label one of each of the following: kinetochore MT, astral MT, polar MT.
Indicate (+) and (-) ends.
B. As the cell progresses through anaphase B, do the bleached spots get closer to,
further from, or stay the same distance from the spindle pole they are embedded
in? Why? Do they get closer to, further from, or stay the same distance from the
plasma membrane? Why?
What
experimental evidence indicates that cyclin B is re-quired for a cell to enter mitosis? What evidence indicates
that cyclin B must be destroyed for a cell to exit mitosis?
In the absence of cdc25 cells would not be able to undergo mitosis.
True or False?
Chapter 13 Solutions
Becker's World of the Cell (9th Edition)
Ch. 13 - Cytoskeletal polymers are modular, and their...Ch. 13 - How could you use paclitaxel, which makes MTs less...Ch. 13 - The amount of dynamic instability exhibited by...Ch. 13 - Prob. 13.3CCCh. 13 - In which of the following cells would you expect...Ch. 13 - Filaments and Tubules. Indicate whether each of...Ch. 13 - True or False. Identify each of the following...Ch. 13 - Prob. 13.3PSCh. 13 - Stabilization and the Critical Concentration....Ch. 13 - Prob. 13.5PS
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The drug chloral hydrate prevents elongation of microtubules by preventing the addition of new subunits to the growing end. During which stage of mitosis would chloral hydrate be most harmful?arrow_forwardList the stages of mitosis in order of occurrence. Describe aunique activity associated with each stagearrow_forwardWhat effect does colchicine have on the percentage of cells in EACH of the stages of mitosis?arrow_forward
- What is the name of the structure that the microtubules bind to during mitosis?arrow_forwardIn mitosis, why do the chromosomes need to condense in prophase and line up in metaphase? (To be clear, this is asking about the usefulness of these specific actions, not just that those things need to happen as part of the overall process.)arrow_forward(b) What is the role of microtubules in mitosis? How does vincristine contribute to the cell cycle arrest of cancer cells? Explain. Microtubulesarrow_forward
- Explain why we can say that M-phase of the cell-cycle is triggered by a positive feedback loop. a) What would the consequences be if cohesins were working normally but condensins were not? and b) what stage of the cell cycle would this cause problems in? Why is it important for the centrosome to duplicate during G1-G2 (interphase) before M phase? The kinetochores serve as a link between the sister chromatids and the microtubules attached to the mitotic spindle. a) How are microtubules still able to exhibit dynamic instability after they are bound to the sister chromatids and b) why is this important to mitosis? As the name suggests, the Anaphase-promoting-complex (APC), promotes the 4th phase of mitosis by separating the sister chromatids so they can travel to separate poles of the cell, and prevents them from being re-zipped together. Describe how APC does these two things (Hint: one involves M-cyclin and the other involves…arrow_forwardBiologists have long been interested in the effects of radiation on cells. In one experiment, researchers examined the effect of radium on mitosis of chick embryo cells growing in culture. A population of experimental cells was examined under the microscope for the number of cells in telophase (as a measure of mitosis occurring) before, during, and after exposure to radium. The results are shown in the Figure. What is the effect of radium exposure on mitosis? Source: R. G. Canti and M. Donaldson. 1926. The effect of radium on mitosis in vitro. Proceedings of the Royal Society of London, Series B, Containing Papers of a Biological Character 100:413419.arrow_forward(c) What are mitotic disrupters? Explain with an example. mitotic disruptersarrow_forward
- The anticancer drug paclitaxel (Taxol), derived from the Pacific Yew, has many effects on mitosis. One of its most powerful effects is that it prevents disassembly of the mitotic spindle, which prevents spindle fibers from shortening. Which phase of mitosis would this directly affect? Why would this stop cell division overall and lead to cell death?arrow_forwardIn the following study, the investigators wanted to determine the role of cyclin B in controlling the cell cycle. Earlier researchers had found that extracts made from frog eggs (Xenopus) contained all the necessary proteins and machinery required for DNA replication. This included proteins that regulated the mitosis promoting factor (MPF). At the time of this study, cyclin B was show to affect MPF activity and the research group wanted to test using Xenopus egg extract in an assay. In Figure 1 (a) MPF activity was tested for its ability to phosphorylate Histone (H1) in sperm chromatin over a certain period of time. Additionally, the cyclin B concentration in the extract was measured. In figure 1b, the extract was tested after treatment with RNase which degraded only the mRNA and not RNA or FRNA in the extract. Knowing that cyclin B is a short-lived protein, why do you suppose the graph shows the results you see in figure 1b?arrow_forwardwhy During Mitosis, Sister ChromatidsSeparate and Two Daughter Nuclei Form?arrow_forward
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