Fundamentals of Biochemistry: Life at the Molecular Level
Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 10, Problem 1MTE
Summary Introduction

To explain: The ion that is transported by the M2 protein and the role of ion transport in the flu virus life cycle.

Concept introduction: The Matrix-2 (M2) protein is an influenza encoded proton-selective ion channel protein. In influenza, M2 protein unit is made up of three segments of proteins that are a transmembrane segment, an intracellular C-terminal domain, and the extra cellular N-terminal domain. The pore of the ion channels produces at the transmembrane segment.

Summary Introduction

To explain: The drugs that target the M2 protein in influenza.

Concept introduction: The Matrix-2 (M2) protein is an influenza encoded proton-selective ion channel protein. In influenza, M2 protein unit made up of three segments of proteins that are a transmembrane segment, an intracellular C-terminal domain, and the extra cellular N-terminal domain. The pore of the ion channels produces at the transmembrane segment.

Summary Introduction

To explain: The reason for developing new drugs to block M2 function.

Concept introduction: The Matrix-2 (M2) protein is an influenza encoded proton-selective ion channel protein. In influenza, M2 protein unit made up of three segments of proteins that are a transmembrane segment, an intracellular C-terminal domain, and the extra cellular N-terminal domain. The pore of the ion channels produces at the transmembrane segment.

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