GENETICS(LL)-W/CONNECT >CUSTOM<
6th Edition
ISBN: 9781260571561
Author: HARTWELL
Publisher: MCG CUSTOM
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Chapter 1, Problem 15P
Mutations in genes that change their pattern of expression (the time and cell type in which the gene product is produced) are thought to be a major factor in the evolution of different organisms. Would you expect the same protein to work in the same way (for example, to perform the same kind of enzymatic reaction) in two different types of cells (for example, cells in the retina of the eye and muscle cells)? Is it possible that the same protein might function in different biochemical pathways in eye cells and muscle cells even if the protein’s basic mechanism always remains the same?
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In humans, the AMY1 gene produces the enzyme amylase in cells of the salivary glands. Amylase breaks down starch (a polysaccharide) into the sugar maltose (a disaccharide). People from cultures with diets high in starch produce more amylase than people from cultures with diets low in starch because of a mutation in the AMY1 gene. Explain in two to three sentences why the frequency of this AMY1 mutation would have increased in frequency in populations with a high starch diet.
Domestic dogs are closely related to wolves. Wolves have one copy of the gene that encodes the enzyme amylase. Amylase is required to digest starch. Dogs have between 4 and 30 copies of this gene. Explain how the new copies arose in the genome of the domestic dog. Compare this to the evolution of lactase persistence in humans. Explain how the diet and environment of a dog compared to a wolf would result in fixation of the duplicated gene. What possible explanation is there for the variation of copy number among dog breeds?
Many aspects of gene function can be nicely explained with the one-gene-one-enzyme hypothesis, which states that a gene controls the production of an enzyme. Which of the following findings about gene expression, though, requires an expansion of this simple concept?
Choose an answer below:
Non-enzyme proteins are made from genes too.
Some genes code for RNA molecules only.
Enzymes composed of different polypeptides are coded for by more than one gene.
a and c, but not b
a, b, and c
Chapter 1 Solutions
GENETICS(LL)-W/CONNECT >CUSTOM<
Ch. 1 - Choose the phrase from the right column that best...Ch. 1 - If one strand of a DNA molecule has the base...Ch. 1 - The size of one copy of the human genome is...Ch. 1 - Indicate whether each of the following words or...Ch. 1 - a. How many different DNA strands composed of 100...Ch. 1 - RNA shares with proteins the ability to fold into...Ch. 1 - The human protein lactate dehydrogenase shown in...Ch. 1 - a. Are the triplets in the genetic code table...Ch. 1 - Why do scientists think that all forms of life on...Ch. 1 - Why would a geneticist study a yeast cell or a...
Ch. 1 - How can a scientist tell if a protein present in...Ch. 1 - Figure 1.6 shows the amino acid sequences of parts...Ch. 1 - Why do scientists think that new genes arise by...Ch. 1 - Explain how the exon/intron structure of genes...Ch. 1 - Mutations in genes that change their pattern of...Ch. 1 - A single zebrafish gene function was inactivated...Ch. 1 - Different mutations in the WDR62 gene that...Ch. 1 - Researchers have successfully used gene therapy to...Ch. 1 - By the time this book is published, it will likely...
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- Various strains of bacteria are able to transfer genes to eukaryotic hosts. This process of horizontal gene transfer often results in the formation of enzymes in the host organism that assist in metabolic pathways. Which of the following is the most likely explanation for why bacterial genes are able to successfully transfer genes that produce enzymes in eukaryotic cells? Bacteria and Eukarya have similar mechanisms for the formation and use of enzymes in metabolic processes. Bacteria and Eukarya use the same enzymes in all of their metabolic processes so the genes are interchangeable. Bacteria and Eukarya share similar reproductive mechanisms so the cells reproduce without recognizing foreign DNA. Bacteria and Eukarya have the same mechanism for replicating DNA so genes can easily be transferred between the two types of cells.arrow_forwardMany aspects of gene function can be nicely explained with the one- gene-one-enzyme hypothesis, which states that a gene controls the production of an enzyme. Which of the following findings about gene expression, though, requires an expansion of this simple concept? Non-enzyme proteins are made from genes too. Some genes code for RNA molecules only. Enzymes composed of different polypeptides are coded for by more than one gene. a and c, but not b a, b, and carrow_forwardVarious strains of bacteria are able to transfer genes to eukaryotic hosts. This process of horizontal gene transfer often results in the formation of enzymes in the host organism that assist in metabolic pathways. Which of the following is the most likely explanation for why bacterial genes are able to successfully transfer genes that produce enzymes in eukaryotic cells? A - Bacteria and Eukarya have similar mechanisms for the formation and use of enzymes in metabolic processes. B - Bacteria and Eukarya use the same enzymes in all of their metabolic processes so the genes are interchangeable. C - Bacteria and Eukarya share similar reproductive mechanisms so the cells reproduce without recognizing foreign DNA. D - Bacteria and Eukarya have the same mechanism for replicating DNA so genes can easily be transferred between the two types of cells.arrow_forward
- Based on our modern understanding, what revisions are necessary to the original one-gene / one-enzyme hypothesis? (Check all that apply.) Alternative splicing allows one gene to encode multiple polypeptides. Some genes encode RNAs, not enzymes. Some genes encode lipids, not enzymes. Some genes encode polypeptides that are not enzymes, such as structural proteins. Proteins as functional units may be composed of several polypeptides, so genes may encode just one polypeptide within a larger protein. Enzymes are not encoded by genes after all — they are constructed through separate biochemical processes.arrow_forwardCreate a Venn diagram to compare and contrast the process of gene expression in Bacteria versus eukaryotes. Remember that “gene expression” can include any part of transcription or translation. Try to be as thorough as you can about what aspects of this process are similar between the two taxa, and what characteristics are distinct to only Bacteria or eukaryotes. Plase include a minimum of 15 items in the Venn diagram.arrow_forwardSuppose that a mutation resulted in a tapeworm that did not have hooks. Assuming this tapeworm was a human parasite, what is the most likely explanation of the effect might this have? The tapeworm would spread throughout the human body. The tapeworm would complete its entire life cycle inside the human host. The tapeworm would not remain in the digestive tract very long. The tapeworm would not be able to enter the human body. The tapeworm would reproduce more to compensate for a lack of hooks.arrow_forward
- You are studying a protein called Fatransformase that affects the saturation of phospholipds in plasma membranes in different species of frogs. You notice that in Froggus goofus and Froggus croakus that the Fatransformase is not active at cold temperatures (below 10oC). Upon closer inspection, you see that each species has a different method of gene expression for the enzyme. In Froggus goofus the Fatransformase protein is present at 10oC in the cells but is not active. In Froggus croakus the protein is not present at all. Indicate the level of regulation (name) that is occurring in each species and include/describe an example of what could be occurring at a molecular level.arrow_forwardThe amino acid asparagine is synthesized from aspartic acid by the enzyme asparagine synthetase (AS). In the previous problem you proposed a model for how this gene could be regulated. Suppose that you carry out an experiment to test your model. To do this you cut out the regulatory sequences upstream of the gene and fuse it to a gene for green fluorescent protein (GFP). Now you can visually observe when the gene is activated. You insert this engineered gene into a host cell and look for GFP expression. You discover some mutants that have different expression levels of GFP and call them GFP1- and GFP2-. The expression levels of GFP are given below. Cell GFP expression Wild type 100 GFP1- 50 GFP2- 0 Propose an explanation for these results based on your model. In other words, what was mutated and how? Your answer should include whether the mutation is (see links for more information): dominant or recessive https://www.ncbi.nlm.nih.gov/books/NBK21578/#A1877…arrow_forwardThe protein produced by the gene represented in Figure 4 participates in the development of two body structures: the mouth and the pelvis. During the adult stage of this organisms the gene is turned off by histones. However, if any organism suffers an injury in the mouth, the gene becomes active again and participates in the wound healing process. Briefly explain a molecular mechanism that could allow the organisms to turn on this gene again. FIGURE 4: Regulatory sequence Regulatory sequence Enhancer 1 Isilencer Open reading frame Enhancer 2 /silencer Promoter S'UTR JUTR Proximal Core Start Stop Terminator DNA TATA Exon 1 Exon 3 Exon 2 intron Intronarrow_forward
- The amino acid asparagine is synthesized from aspartic acid by the enzyme asparagine synthetase (AS). In the previous problem you proposed a model for how this gene could be regulated. Suppose that you carry out an experiment to test your model. To do this you cut out the regulatory sequences upstream of the gene and fuse it to a gene for green fluorescent protein (GFP). Now you can visually observe when the gene is activated. You insert this engineered gene into a host cell and look for GFP expression. You discover some mutants that have different expression levels of GFP and call them GFP1- and GFP2-. The expression levels of GFP are given below. Cell GFP expression Wild type 100 GFP1- 50 GFP2- 0 Propose an explanation for these results based on your model. In other words, what was mutated and how? This answer should include whether the mutation is (view links for more information): dominant or recessive https://www.ncbi.nlm.nih.gov/books/NBK21578/#A1877 in a cis…arrow_forwardConsider Molecule X, which is found in all living cells. This molecule is transcribed from a stretch of DNA in the nucleus. Each nucleobase on the DNA produces a matching nucleobase on this molecule. Every 3-base codon specifies an amino acid in a protein. What is the name of X? Your answer should be one word, or a short two- or three-word phrase. Spelling counts. Note: if there is more than one possible answer, separate each answer with a comma. x 5arrow_forwardBacteria are often the preferred hosts for genetic engineering projects by splicing in novel genes from eukaryotes into plasmids, which are moved into competent bacteria. For instance, the gene for human insulin was isolated and moved into a bacterium, which can now produce the much-needed chemical. Previously, type 1 diabetics had to rely on professionals that gathered insulin from human cadavers, cows, and pigs. In order for this feat of genetic engineering to occur, researchers had to start with an unspliced mRNA transcript for h insulin. Agree/Disagree? Explain your response.arrow_forward
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