Based on our modern understanding, what revisions are necessary to the original one-gene / one-enzyme hypothesis? (Check all that apply.)

An example sequence corresponds to human sickle cell beta-globin mRNA and that this disease results from a point mutation in the β globin gene. In the following section, you will compare sickle cell and normal β globin sequences to reveal the nature of the sickle cell mutation at the protein level. To do this you need to find at least one sequence representing the normal beta globin gene. Open a new window and visit the NCBI home page(http://www.ncbi.nlm.nih.gov) and select “Nucleotide” from the drop menu associated with the top search box. Then enter the search term: HBB . Note that lots of irrelevant results are returned so let's apply some “Filters” (available by clicking in the left-hand sidebar) to focus on RefSeq entries for Homo sapiens. Remember that we are after mRNA so we can compare to the mRNA sequence from part 1 above. QUESTION #1: What is the ACCESSION number of the “Homo sapiens hemoglobin, beta (HBB), mRNA” entry?    NOTE: Boolean operators (NOT, AND, OR) as…

The lacheinmal protein is a hypothetical protein that causes people to smile more often. it is inactive in many chronically unhappy people. the mRNA isolated from a number of different unhappy individuals in the same family was found to lack an internal stretch of 173 nucleotides that is present in the lacheinmal mRNA isolated from happy members of the same family. the DNA sequences of the Lacheinmal genes from the happy and unhappy family members were determined and compared. they differed by a single nucleotide substitution, which lay in an intron. What can you say about the molecular basis of unhappiness in this family?

What are the key properties of the genetic code? Given that the genomes of all organisms are made up of As, Ts, Cs, and Gs, how does one account for diversity in organisms? What are some factors that could adversely affect diversity in nature?

3)Which of the following statements are true? Choose all that apply a)There are multiple codons possible for nearly all amino acids b)Each stop codon also codes for an amino acid c)Each tRNA will base pair with only one codon d)The start codon also codes for an amino acid e)Each codon in mRNA codes for exactly one amino acid f)Each codon in tRNA codes for exactly one amino acid g)Each anticodon in tRNA pairs with exactly one codon h)Each tRNA carries exactly one type of amino acid