Concept explainers
Suppose a woman who is a carrier of sickle-cell trait (making her a heterozygote) has children with a man who is totally healthy and does not carry the gene for sickle-cell trait at all. Which one of the following is true about their potential children? (Draw a Punnett square on scratch paper if it helps you.)
A) None of their children will have sickle-cell disease.
B) All of their children will have sickle-cell disease.
C) All of the couple's children would be heterozygous carriers like the mother.
Sickle cell anemia is an autosomal recessive disorder. There is a mutation in the single base pair of DNA that leads to the formation of an abnormal chain of hemoglobin. Normally the 6th codon codes for glutamic acid, but in sickle cell anemia is valine.
A woman who is a carrier of sickle cell anemia. She must be heterozygous ( two different alleles for a gene.)
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