Why is the covalent intermediate of elastase stable at low pH? The catalytic histidine cannot act as general acid when protonated. The catalytic histidine cannot act as a general base when protonated. O The catalytic serine cannot form a covalent bond to substrate if the pH is below 7.4. The catalytic serine cannot preferentially form a hydrogen bond with the catalytic histidine at acidic pH, causing these residues to shift out of their catalytically optimal positions.
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
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