Why is fetal hemoglobin’s affinity for O2 greater than that of maternal hemoglobin?
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Why is fetal hemoglobin’s affinity for O2 greater than that
of maternal hemoglobin?
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Solved in 3 steps
- How does the oxygen-binding curve of fetal hemoglobin differ from that of adult hemoglobin?What is hemoglobin F?Why does the fetus need adifferent hemoglobin?What would happen to a fetus if hemoglobin of the maternal blood hadan affinity for O2 that was equal to or greater than the hemoglobinof fetal blood?
- How does the movement of CO2 from fetal blood into maternal bloodincrease the movement of O2 from maternal blood into fetal blood?(Hint: Consider the shift of the oxygen-hemoglobin dissociation curve.)HOW Different Hemoglobins Are Expressed atDifferent Developmental Stages?Oxygen affinity of fetal blood is higher than that of maternal blood and may help to provide the fetus with an adequate oxygen supply during pregnancy. In mammals, 2, 3-biphosphosphoglycerate (BPG) mediates intracellular hemoglobin function by lowering cxygen affinity. Fetal red blood cells have higher affinity for oxygen because of a smaller effect of BPG on oxygen affinity of fetal hemoglobin (Hb F) compared with adult Hb (Hb A). Which symbol shows the PS0 value corresponding to Hb F? 14 12 10 0.0 0.5 1.0 1.5 2.0 2,3-BPG (mM) O Crcle O Dimond O Square O Triangle (6H ww) d