In an alpha helical protein that spans a cell membrane,the membrane whilewould likely be associated with the aqueous environmentO His; Ser; ThrCIle; Asn; GluTyr; Glu; GlyTrp: Asn; Ala(Ctrl)would likely be in the center ofwould likely be associated with the polar head groups and

The amino acids are classified as polar and non-polar. The integral membrane proteins are…

Answered: would likely be in the center of would…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Most of the GLP-1 receptor structure form part of the transmembrane domain (TMD) that is embedded in the plasma membrane. The TMD enables the transmission of signal induced by the binding of GLP-1 from outside the cell into the cytoplasm of the cell, which in turn initiates a signaling cascade that ultimately leads to insulin secretion. Is the TMD of the receptor mainly hydrophobic or hydrophilic? Explain your answer in 1 – 3 sentences.
Which of the following statements is true O Sphingomyelin posses phosphoryl serine in addition to two long hydrocarbon chains, one contributed by a fatty acid and the other by sphingosine OLipid compositions of membrane mono-layers are symmetrical O Unsaturated fatty acids have double bond(s) in the cis configuration In ABO blood typing, lack of glycosyltransferase and galactosyltransferase produces AB blood group
Concerning enzymatic activity, a larger Km value indicates a/an: Select one: O lower affinity for its substrate O inhibitory process O larger enzyme O larger Vmax O greater affinity for the substrate Which is the least common type of chemical bond? Select one: O Hydrogen O Peptide O Covalent O lonic O Disulphide D-gluconic acid is: Select one: O an integral membrane protein O a codon O an oxidized sugar O phosphorylated O a large lipid molecule
A transmembrane protein helps catalyze the transport of solute A from the INSIDE TO the OUTSIDE of a cell. The reaction can be represented by the reaction coordinate diagram below. It is possible to conclude that the concentration of A on the outside of the cell is than its concentration on the inside AND that it is_ to expect that the protein will at some point form a continuous path between th cytosol and the extracellular environment. A inside A outside reaction coordinate O lower; reasonable O higher; unreasonable O higher; reasonable free energy
GLUT4 is a protein channel that facilitates the transport of glucose into the cell. Under nor- mal conditions, some of the GLUT4 proteins that are synthesized by the cell do not become active and are instead stored within the membranes of vesicles. The insulin receptor tyrosine kinase (TRK) is a receptor protein that facilitates the decrease of glucose concentration in the bloodstream by increasing the uptake of glucose by cells. When the insulin hormone binds the insulin TRK receptor, a signal transduction pathway causes the activation and addition of GLUT4 to the cell membrane. A model of this signal transduction pathway is illustrated in the figure below. insulin insulin receptor cytoplasm A model of the insulin TRK receptor signal-transduction pathway. Which of the following best predicts the effect of a loss of function of the insulin TRK2 A B C D The stimulation of the signal transduction pathway will increase. The storage of GLUT4 inside the cell will increase. The concentration…
The majority of amino acid residues found in the portion of a beta-barrel in contact with the transported solute are O hydrophobic O cyclic O hydrophilic O aromatic Previous Nort
Small molecules are used as inhibitors of protein action - as drugs. They most often do this by blocking the active site within the protein. Potential drugs can be screened computationally to determine if they are strongly bound to the protein. Figure 1 shows a possible conformation of a candidate drug molecule, 4-bromo-2- carboxymethylamide-pyrrole (abbreviation: BCMAP) at the active site of a protein (abbreviation: PR). Figure 2 shows the full protein structure whilst figure 3 shows a known inhibitor of the protein at the site, overlayed with another calculated conformer of BCMAP. (a) Explain what types of interactions, both intermolecular and intramolecular, that a molecular mechanics forcefield must be able to describe in order to be able to accurately determine the geometry of BCMAP in the protein. Identify which interactions will be the most important to describe accurately. Figure 1.4-bromo-2-carboxymethylamide-pyrrole (BCMAP) (C, N, O, and Br atoms in yellow, blue, red, and…
What are some of the interactions made between ATP and the kinase? Can you please describe bonds that the protein makes with (a) the phosphate groups, (b) the sugar, and (c) the adenine base? Please don't just copy answers from google.. I already read most of em.. :(
Please note whether each protein is either a Kinase (K), ATPase (A), GTPase (G), Membrane protein (M). Some proteins may need more than one letter: Dynamin [Choose ] Porin [Choose ] EGF Receptor [Choose ] CD4 [Choose ] P-glycoprotein [Choose ] Rho [Choose ] <
You have a mixture of positive, negative and neutral proteins. In order to obtain a pure positively charged protein, you can pass this mixture through a column containing G-50 coarse beads Anion Exchanger beads Cation Exchanger beads G-50 superfine beads
1. The CFTR protein is a chloride channel in the cell membrane. Use your understanding of the biochemical properties/categories of amino acids and how they interact with membrane phospholipids to predict the distribution of charged/polar, and non-polar amino acids within the domains of CFTR listed below. Consider one category to include the charged amino acids and the polar amino acids and the other category to include the non-polar amino acids. For each domain, predict which category of amino acids is likely to be most abundant. Also, explain the rationale behind your prediction. Protein domain Prediction (Charged/Polar or Non-Polar amino acids?) Explanation for prediction TMD1 and TMD2 (transmembrane domains, parts 1-12) ECLs and ICLs (extracellular and intracellular loops) NBD1 and NBD2 R
Which of the following protein should coat a vesicle that contains a receptor that can recognize the proteins having the following amino acid sequence Lysine (K), Aspartic Acid (D), Glutamic acid (E), Leucine (L)? Group of answer choices COP I COP II All of the other/above

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would likely be in the center of would likely be associated with the polar head groups and In an alpha helical protein that spans a cell membrane,. the membrane while would likely be associated with the aqueous environment His; Ser; Thr Ile; Asn; Glu Tyr; Glu; Glx. Trp: Asn; Ala (Ctrl) -