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- Which of the following statements concerning gluconeogenesis is NOT true? a. Gluconeogenesis is to make glucose from glycogen. b. Many of the reactions of gluconeogenesis are glycolytic reactions going in reverse. c. The process of gluconeogenesis consumes ATP. d. The process of gluconeogenesis is regulated by ATP. e. Gluconeogenesis maintains the blood glucose level long after all dietary glucose has been absorbed and oxidized.From the choices below which of the following statement about glycogen and its catabolism is incorrect?a. The function of glycogen in the liver is to supply glucose to the blood when neededb. Muscle, but not liver, has the enzyme glucose-6-phosphatasec. When glycogenolysis is active in muscle, glycolysis is usually actived. the function of glycogen in muscle is to supply energy for muscle contractionGlycogenesis occurs in both muscle and liver. Select one: O True O False Glycogen is released from the muscle due to increased CAMP due to: Select one: O a. Growth hormone O b. Epinephrine O c. Thyroxine O d. Glucagon UDP-Glucose is converted to UDP-glucoronic acid by: Select one: O a. NADP O b. ATP O c. GTP O d. FAD O e. NAD In the fasted state gluconeogenesis is promote by which enzyme Select one: O a. Fructose 2,6 bisphosphate induced stimulation of phosphofructokinase-1 O b. Acteyl CoA induced stimulation of pyruvate carboxylase O c. Citrate induced stimulation of Acetyl CoA decarboxylase Glyconeogenesis prevents hypoglycemia during prolonged fasting. Select one: O True O False
- Which of the following statements regarding glycogen are true? A. Glucose from glycogen can be metabolized anaerobically B. Approximately 1-2% of muscle weight is glycogen, whereas 10-15% of liver weight is glycogen C. It is faster for the muscle to obtain energy from glycogen than from lipids D. A and B are true E. B and C are true F. Both A, B, and C are trueWhich of the following steps does NOT require ATP? O A. Conversion of glucose to glucose 6-phosphate O B. Conversion of malate to pyruvate O C. Conversion of pyruvate to oxaloacetate O D. Activation of hormone sensitive lipase by PKA O E. Inactivation of glycogen synthase by PKA is an intermediate metabolite linkage between carbohydrate and fat metabolism. O A. Malate O B. Oxaloacetate OC. Glucose 6-P O D. Acetyl COA O E. Malonyl COAAccording to glycogen metabolism, which of the following statementsis/are not true? I. Insulin results in dephosphorylation and subsequentactivation ofglycogen synthase. II. cAMP is a second messenger that triggers an increase in glycogensynthesis. III. Release of epinephrine leads to increased glycogen breakdown. IV. Glucagon promotes glycogen breakdown. V. Glucose-6-phosphate is an allosteric inhibitor of.phosphorylase A) I and VB) III and VC) II onlyD) III and IVE) V only
- Which of the following statements about Pyruvate Kinase is true? a. Pyruvate kinase is activated by Fructose 1,6-bisphosphate b. Pyruvate kinase is inactivated by the Hormone Insulin c. Pyruvate kinase is activated by the hormone Glucagon d. Pyruvate Kinase is activated by Fructose 1,6-bisphosphateAt high energy charge (ATP/AMP ratio) AND low blood glucose levels a. Pyruvate is converted to glucose via gluconeogenesis b. Glycolysis is activated c. Fatty acids are converted to Acetyl-coA d. Gluconeogenesis is inhibitedInsulin stimulates which of the following pathways? a. Gluconeogenesis b. Triacylglycerol synthesis and storage c. Lipolysis and fatty acid mobilization d. Glycogen breakdown
- A major pathway for metabolism of ethanol is shown below. Humans consuming a large fraction of their calories in the form of ethanol may become hypoglycemic. This is because: Ethanol is a good solvent, and it dissolves the membranes of the mitochondria, where some of the gluconeogenic enzymes reside. b. Ethanol metabolism indirectly inhibits pyruvate kinase, by consuming NAD. d. Ethanol metabolism indirectly inhibits lactate dehydrogenase, by consuming NAD. f. The assertion in the question is incorrect, because acetyl-CoA can be used for synthesis of glucose. g. Ethanol metabolism indirectly inhibits pyruvate carboxylase, by consuming NAD. h. Ethanol metabolism indirectly inhibits phosphoenolpyruvate carboxykinase, by consuming NAD.Which of the following statements about the integration of fat and carbohydrate metabolism control is correct? a. High insulin/glucagon ratio activates lipolysis in muscle b. High insulin/glucagon ratio inhibits lipogenesis in liver. c. Low insulin/glucagon ratio activates lipolysis in adipocytes. d. Insulin-dependent glucose transporters are recruited to their functional membrane site when insulin levels are lowGlucose-6-phosphate isomerase is used to do which of the following steps of glycolysis Select one: a. Glucose-6-phosphate is converted to Fructose-6-phosphate b. 3-phosphoglycerate is converted 2-phosphoglycerate c. Glyceraldehyde-3-phosphate is converted to 1,3 Bisphosphoglycerate d. Glucose is converted to Glucose-6-phosphate e. Dihydroxyacetone (Glycerone Phosphate) is converted to Glyceraldehyde-3-phosphate f. Fructose-1,6 Bisphosphate is converted to Dihydroxyacetone and Glyceraldehyde-3-phosphate g. 1,3 Bisphosphoglycerate is converted to 3-phosphoglycerate h. Phosphoenolpyruvate is converted to pyruvate i. Fructose-6-phosphate is converted to Fructose-1,6,bisphosphate j. 2-phosphoglycerate is converted to Phosphoenolpyruvate