Which component of cell division machinery is frequently targeted by anti-cancer drugs? Can you explain the common side-effects of chemotherapy (e.g. hair loss, mucositis) based on this information?

The best strategy for treating a specific type of human tumor can depend on identifying the type of cell that became cancerous to give rise to the tumor. For some tumors that have colonized a distant location (metastasized), identifying the parental cell type can be difficult. Because the type of IF protein expressed is cell-type-specific, using monoclonal antibodies that react with only one type of IF protein can help in this identification. What IF proteins would you produce monoclonal antibodies against to identify (a) a sarcoma of muscle cell origin, (b) an epithelial cell carcinoma, and (c) an astrocytoma (glial cell tumor)?

Understand how a cancer cell from a primary benign tumor is able to leave the primary benign tumor and enter the blood stream or lymph (migration), start to adhere and grow in a nearby environment like a blood vessel near an organ (invasion) and enter into a new organ to grow and form a secondary tumor ( extravasation). What proteins would be involved in these steps and what molecular changes in the ECM or basal lamina would need to occur as well as the cancer cell for this process to happen.

Compare and contrast the intrinsic and extrinsic apoptosis pathways. Please keep brief - 3 sentences/dot points each.