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- Compare and contrast formulation of long acting insulin and short acting insulin. How do their properties help control the rate at which the Delivered insulin enters bloodstream?What happens to the insulin-secreting capacity of a type 2 diabetic placed on insulin therapy earlier than recommended? Can the external supply of insulin improve the functional capacity of the insulin-secreting cells, to some extent by providing some rest to these cells? Is inhaled insulin a suitable substitute for injectable insulin? Is there, or will there soon be, insulin in the form of a tablet?What is physiological mechanism of steroid-induced diabetes development? What treatment should be recommended? Give some causes of steroid-induced diabetes.
- What are the major differences between type 1 and type 2 diabetes in relation to insulin?If we use a normal sodium chloride solution instead of PBS buffer during insulin extraction ,what will happen?What is the second messenger for the insulin response? What is the link between insulin binding to the receptor and the eventual second messenger?
- Which are major controlling factor for insulin secretion is the plasma glucose concentration?Explain what biochemical pathway/metabolic processes are affected in insulin resistance? How does this affect glycogen breakdown and gluconeogenesis.Why do you suppose individuals with diabetes must receive insulin subcutaneously by injection rather than orally?