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- What are MTPs ? Under what conditions MTPs are legally permitted?Which signaling molecule or molecules bind to a G-protein coupled receptor? (note: there may or may not be more then one answer) a) cortisol b) insulin c) glucagon d) calcium e) cyclic AMP f) epinephrineWhich of the following would result in an INCREASE in BLOOD glucose levels ? choose all of the options that apply. a)AKT mutation that makes it inactive b)A mutation in TBC1D4 that renders it inactive at all times. c)RAB10 has a mutation that boosts its GTPase activity. d) GSK3beta has a mutation that makes it always off. e) The insulin receptor has a mutation that precludes dimerization.
- What is the primary intracellular signaling factor activated during aerobic exercise? What is an ultimate outcome of activating this factorDespite the fact that many peptides have critical physiological functions(e.g., as hormones, neurotransmitters, antibacterial toxins), they are not considered to be ideal as drugs. The following questions illustrate some of the issues that limit the use of peptides as therapeutics.(a) Insulin is a peptide therapeutic used to manage Type 1 diabetes, whichaffects more than 20 million people worldwide according to the International Diabetes Federation. A significant limitation to the broad distribution and use of insulin to treat Type 1 diabetes is the fact that it must be administered by injection rather than orally. Why is insulin administered by injection and not orally?(b) Many of the D-amino acids found in nature have been discovered inbacterially produced peptides that have antibiotic properties. Bacteriasecrete these peptides into their environments to kill competitor bacteriaand thereby gain a selective advantage. Given your answer to part (a) ofthis question, what potential…How would you test the neurotrophic theory, knowing that the most potent neurotrophic factor is NGF? Propose and describe an experimental design. The strategy should include treatments and controls, it should indicate what outcomes you would look for, and what they mean.
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