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How can bacteria produce
human insulin on an industrial
scale? What are the other
forms of insulin made
available by the
pharmaceutical industry?
Biotechnology deal with biological and biopharmaceuticals. Biotechnology applied in diagnostic, therapeutic, genetically modified crops for agriculture, bioremediation, processed food, etc.
With the help of genetically engineering which comes under biotechnology, insulin is formed for diabetes patients.
Step by step
Solved in 2 steps
- What is the raw material used for human insulin produced using E.coli? What is the stoichiometric equation of insulin production?From which species human insulin is being commercially produces?64 An investigator is studying the mechanism of action of an insulin-sensitizing drug. The addition of the drug to cultured mouse hepatocytes is observed, and results show increased phosphorylation and inhibition of acetyl-CoA carboxylase Which of the following processes is most likely inhibited by this action of the drug? A) Fatty acid oxidation B) Fatty acid synthesis C) Glycogen synthesis D) Glycolysis E) Protein synthesis
- It is noticed that when a strain of mice exercises, their blood glucose drops to very low levels. Which of the following can explain this situation? a) These mice do not make enough insulin b) these mice lack insulin receptors on their cells c)these mice lack glucagon d) these mice cannot synthesize glycogen from glucoseName the genetically engineered human Insulin?Select all that is correct. 1) C-peptide is not present in mature insulin. 2) The insulin produced by rDNA technology has C-peptide. 3) The pro-insulin has C-peptide. 4) A-peptide and B-peptide of insulin are interconnected by disulphide bridges.
- There are several applications of microorganisms in industries. One of them is in medical and pharmaceuticals. Name a suitable microorganism and demonstrate its application in producing synthetic human insulin.In 2-page worth of words (around 500), discuss CYCLAMATE's regulation, allowable levels, and what group of people are at high risk for the side effects of CYCLAMATE in the body.What is role of insulin in human body?
- What is the importance in glycosylation in rtPA in terms of its activity as a protein therapeutic?Despite the fact that many peptides have critical physiological functions(e.g., as hormones, neurotransmitters, antibacterial toxins), they are not considered to be ideal as drugs. The following questions illustrate some of the issues that limit the use of peptides as therapeutics.(a) Insulin is a peptide therapeutic used to manage Type 1 diabetes, whichaffects more than 20 million people worldwide according to the International Diabetes Federation. A significant limitation to the broad distribution and use of insulin to treat Type 1 diabetes is the fact that it must be administered by injection rather than orally. Why is insulin administered by injection and not orally?(b) Many of the D-amino acids found in nature have been discovered inbacterially produced peptides that have antibiotic properties. Bacteriasecrete these peptides into their environments to kill competitor bacteriaand thereby gain a selective advantage. Given your answer to part (a) ofthis question, what potential…In what way has the production of human insulin by recombinant DNA methods had significant medical advantages for diabetics?