What is the Chi-squared Goodness of Fit test used to test? a. If the disease is due to environmental or genetic factors. b. The name of the disease gene. c. Whether the disease follows a AR or AD mode of inheritance at the disease gene. d. If the p-value is greater than 0.05. e. If the observed data is consistent with the specified mode of inheritance at a given disease gene.
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What is the Chi-squared Goodness of Fit test used to test?
a. If the disease is due to environmental or genetic factors.
b. The name of the disease gene.
c. Whether the disease follows a AR or AD mode of inheritance at the disease gene.
d. If the p-value is greater than 0.05.
e. If the observed data is consistent with the specified mode of inheritance at a given disease gene.
The Chi-square test is used in genetics to find out whether there is a difference in observed and predicted frequency. It illustrates whether the two genes are linked or unlinked just by observing the frequency distribution of the phenotypes.
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- А. I. For A and B, 1. Identify the type of inheritance. Justify your answer. 2. Decode the genotypes of the individuals in pedigree. (Use for the letter A representation alleles.) of 2 3. List down all affected II individuals. 1 6 7 8 2 4 II 1 2 3 4 5 6 7 8 9 3. B.Please Answer with reason: 3) The nurse is explaining the inheritance of Huntington disease (autosomal dominant) to a newly diagnosed patient whose partner does not have the gene mutation. Which statement should the nurse make regarding family planning? a. There is a 100% chance with each pregnancy that the child will inherit the gene for Huntington disease. c. There is a 50% chance with each pregnancy that the child will inherit the gene for Huntington disease b. There is a 25% chance with each pregnancy that the child will inherit the gene for Huntington disease d. There is a 0% chance with each pregnancy that the child will inherit the gene for Huntington disease.Match the following terms with their correct definitions. A change in a gene that causes it to produce no protein. A loss-of-funtion in one allele that is uominant because the wild type allele alone does not produce enough protein to serve its typical role. 1. Loss-of-function mutation 2. Null mutation 3. Gain-of-function mutation A change in a gene that causes it to produce less protein or protein that is not able to serve its typical role. 4. Haploinsufficiency A change in a gene that causes it to produce increased protein or protein that takes on a new role.
- You suspected a genetic condition in an affected childe with a familial form of autism. You requested a genetic test to confirm your clinical impression. This test is considered: A. Carrier screening 63. B. Predictive testing C. Diagnostic testing D. Preimplantation genetic diagnosis (PGD) E. Presymptomatic testing Answer: CThe linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%. In a large sample of the Venezuelan family, what percentage of people would inherit the DNA sequence but not the Huntington’s allele (i.e. be a false positive test for Huntington’s)? What percentage of that large Venezuelan family would not inherit the DNA sequence but would inherit the Huntington’s allele (i.e., be a false negative test for Huntington’s)?Select all the characteristics that make sickle-cell disease a good candidate to study genetic diseases. (Check all that apply.) Check All That Apply It is easily identifiable by a physical characteristic.It is easily identifiable by a physical characteristic. It results from a single change in a single gene.It results from a single change in a single gene. It can be influenced by the environment.It can be influenced by the environment. The sickle-cell inheritance pattern is not influenced by other genes.The sickle-cell inheritance pattern is not influenced by other genes.
- Match the following : Genetic testing Genetic screening Genetic screening programs Genetic screening opportunities A test with high senstivity A test with high specificity predictive tests Pre- symptomatic tests Pre dispositional test involves testing individuals for the genetic change underlying a condition for which there is no evidence. can show that an individual is more likely than others to develop a specified condition. indicate the presence of a causative genotype but the onset of signs and symptoms is not certain. are offered as part of our public health service. do not include conditions that show incomplete penetrance. is performed cases where the onset of signs and symptoms is considered inevitable. involves testing individuals for the genetic change underlying a condition for which there is evidence. has a low false positive rate has a low false negative rate9. F. A. B. E. C. D. The allele for normal skin pigmentation (A) is dominant to absence of pigmentation (a), albinism. Answer the following questions about the inheritance of this disease. What is the genotype of a woman with normal skin pigmentation who has a baby that is an albino? What is the genotype of the baby in A above? did not have the Can 2 people with normally pigmented skin have a baby that is an albino? Explain your answer. If 2 heterozygous people marry, what is the chance that their first child is an albino? Explain your answer. for the the If the first child from E above is an albino, what is the chance the second child is normal? Explain your answer. Can 2 people who are both albinos have a child who is not an albino? Explain your answer. 403. D. A. B. C. 10. Familial hypercholesterolemia is the most common genetic cause of heart disease. It is caused by a dominant factor (C). The recessive factor (c) produces a protein that processes cholesterol normally and leads to a normal risk for heart disease. Answer the following questions about the inheritance of this disease. What is the phenotype of a woman whose genotype is Cc? What is the genotype of a man who has hypercholesterolemia but whose mother did not have the disease? If a man who is heterozygous for the disease marries a woman who is heterozygous for the disease, what is the chance that any child of theirs will inherit the disease? If a man who is homozygous dominant marries a woman who is homozygous recessive, what would you predict for the the genotypes and phenotypes of their children? If the first 2 children from the marriage described in D above have the disease, what is the chance that a third child would be normal? Explain your answer. 41
- a. What type of plot is this? What do the little dots above the dotted line represent? b. The labels above the peaks represent human gene names involved in ALS. Based on the data shown here, which would be the first gene you'd like to investigate further and why?For gain-of-function disorders, which of the following treatment strategies is the be . A. Gene augmentation B.Supply healthy cells . C.Supply normal form of proteins encoded by wild-type allele . D. Gene silencingWhich of the following statements about Mendelian or complex disease is TRUE? Question options: Genetic methods for studying Mendelian phenotypes, such as crossing, is not useful for mapping quantitative trait loci. Mapping of quantitative trait loci does relies on genetic variations that directly contribute to the trait of interest. Both Mendelian and complex traits are associated with single gene locus. Genetic factors determine Mendelian traits, while environmental factors determine complex traits. Genome-wide association studies rely on polymorphic markers that are in linkage disequilibrium with alleles that contribute to the trait of interest.