What exactly are prodrugs? How do enzyme inhibition and induction impact the therapeutic action of a prodrug?
Q: Why Pancillin G is more potent than Nafcillin sodum and Methicillin sodium?
A: A bacterium is a cell, complete with a cell membrane primarily made of lipids. It also contains…
Q: Match if the following is CYP inducer or inhibitor Choices: 1. Ketaconazole Inducer 2.…
A:
Q: What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product?
A: Introduction: Bioavailability is a proportion of the rate and part of the underlying portion of a…
Q: Which phase of cell growth is disrupted by antimetabolites? Explain how folate functions as…
A: Antimetabolites are the cytotoxic type of drug because they kill cells, they done their work by…
Q: elaborate about drug metabolism phases: phase I (oxidation, reduction, hydrolysis) Phase II…
A: Phase I: Yields a polar, water-soluble, metabolite that is often still active. Many of the products…
Q: With the aid of diagrams, illustrate the biochemical basis of the following: Allopurinol used in…
A: Allopurinol used in the management of gout Gout is an inflammatory arthritis that is caused by…
Q: What is the weight of epinephrine (in grams) required to make the prescription? What is the volume…
A: Epinephrine hydrochloride is also known as adrenaline, it is a neurotransmitter and hormone that is…
Q: What are the limitations of Etelcalcetide, and how can the structure of the drug be modified to…
A: Introduction Etelcalcetide is a calcimimetic agent that intensifies the activation of…
Q: what is the mechanism of action and spectrum of activity of Levofloxacin? is this antibiotic…
A: Antibiotics are antibacterial that kills the bacteria (bactericidal) or slows down the growth of…
Q: Why is it better for a drug to be microbicidal than microbistatic?
A: Any substance which is produced by naturally, artificially or through synthetic origin that kills or…
Q: What are the two most Resistant, and the two most Sensitive microbial structures to antiseptic…
A: Biocides: It is the term used to portray the chemical entity or the living organic entity that can…
Q: Why steroid therapy is used as prophylactic in asthma treatment?
A: Asthma is caused by the exposure of the allergens to external chemicals affecting the respiratory…
Q: What are the primary medical practices that result in antimicrobial drug resistance? How can these…
A: This problem has resulted because of the increasing use of antibiotics and antimalarials;…
Q: What is the generic name, therapeutic category, and available dosage forms of Bactroban®,…
A: Generic names are the shorthand name of the drug's chemical name, formula, or structure. Sometimes…
Q: What is the generic name, therapeutic category, and available dosage forms of Feosol®, Fluimucil®,…
A: The details of the drugs given in the table below-
Q: Describe the mechanism of action of an ACE inhibitor. Based on this mechanism, when would ACE…
A: Blood is a fluid connective tissue circulated throughout the body through the blood vessels. The…
Q: What is the generic name, therapeutic category, and available dosage forms of Acalka®, Akineton®,…
A: Generic name:- It is a name given to a drug which is accepted throughout the world. It is not…
Q: List and describe the biochemical assays used to identify the pathogenic Neisseria
A: INTRODUCTION Neisseira The genus Neisseria consist of gram negative, aerobic, non sporulating, non…
Q: What is the generic name, therapeutic category, and available dosage forms of Dilatrend® and…
A: Dilatrend The generic name for the dilated is carvidol. therapeutic category: it comes under the…
Q: Where do chemotherapeutic agents come from?
A: Chemo means chemicals and therapeutic means which has therapeutic ( curing ) effects on body.…
Q: Determine Km and Vmax using Lineweaver-Burke in the presence and absence of inhibitor. What type of…
A: Michaelis menten constant, Km is the substrate concentration required to produce half maximum…
Q: is Polymyxin a cationic antimcrobial peptide? Does Aureomycin targets lipopolysaccharide?
A: is Polymyxin a cationic antimcrobial peptide? Yes
Q: What are the major causes of the ineffectiveness of anticancer therapies?
A: Anticancer Therapies : The therapies which can destroy cancer cells are called anticancer therapies.…
Q: How do uncoupling agents work?
A: Uncoupling agents are also known as uncoupler. They are molecules that disrupts the oxidative…
Q: What is the molecular site of oligomycin action?
A: Oligomycin is a macrolide. It is produced naturally by Streptomyces. It is an inhibitor of the…
Q: How can drug resistance in microorganisms be circumvented?
A: The uselessness of a treatment, such as an antibiotic or antineoplastic, for curing a disease or…
Q: Summarize the mechanism of action and the therapeutic use of the following antifungal drugs:…
A: Antifungal drugs are used to stop or inhibit the growth of fungus.
Q: Match these drugs with the following functions Cell wall synthesis inhibitors 50s Ribosomal…
A: The antibiotics are compounds that act by selectively targeting crucial cellular pathways in…
Q: an improve pharmacodynamic properties of H1-Antihistamine drugs?
A: Drugs are the substances taken to treat a certain complication or a disease in our body that help to…
Q: Identify the bioactive nancomposites for biomedical application ?
A: Bioactivity:It is the ability of a material to incite a very specific biological reaction, usually…
Q: Where is the site of action of inhibitor 2?
A: Inhibitors are the substances that interrupt the interaction of enzyme and substrate complex.
Q: Selective COX-2 inhibitors are preferable than nonselective COX- inhibitors. How can selective COX-2…
A: The type of anti-inflammatory non-steroidal drug are called as NSAIDs or Selective COX-2 inhibitors.…
Q: how does the ratio of cholesterol to phospholipids in a liposome affect drug encapsulation?
A: Phospholipids are a type of chemical molecule that has a hydrophilic head composed of a phosphate…
Q: Why antifolate use for anticancer?
A: Antifolates are compounds that are commonly used to treat different forms of cancer. They are the…
Q: What modifications can be done to streptomycin's structure to enhance its pharmacokinetics and…
A: Streptomycin is the primary found aminoglycoside antibiotic, initially isolated from the micro…
Q: Explain the mechanism of action for Alteplase as a treatment for Stroke?
A: Stroke is a neurological disorder ,it occurs when blood supply to part of the brain is reduced,…
Q: What is the target for the antibiotics such as Chloramphenicol, Oxazolidones, Isoniazid, Ethambutol,…
A: It is required to identify the targets for the antibiotics like Chloramphenicol, Oxazolidones,…
Q: What is the relationship between the zone of inhibition and antibiotic concentration and what is the…
A: The zone of inhibition is a circular area around the spot of the antibiotic in which the bacteria…
Q: Which HDAC inhibitors are used as anticancer agents?
A: Histone deacetylase(HDAC) Inhibitors are a class of anti cancer agents that induces apoptosis…
Q: What are the tests to determine the level of antimicrobial activity of a antimicrobial agent? How…
A: Antibiotic disc diffusion study is also known as the Kirby-Bauer method in which the susceptibility…
Q: How are dilution susceptibility tests and disc diffusion tests usedto determine microbial drug…
A: Although not all infectious agents require antimicrobial sensitivity testing, it is essential in…
Q: What is the biochemical basis of allopurinol treatment for gout?
A: Gout is a form of arthritis that is characterized by severe pain, redness, and tenderness in joints.…
Q: What is the chemical and therapeutic classification of Isoniazid (drug) ?
A: In this question, we have to answer the chemical and therapeutic classification of Isoniazid (drug).
Q: Why gentamicin and tetracycline are not effective against eukaryotic microorganisms such as fungi?
A: Tetracycline and gentamicin are antimicrobial agents.
Q: Discuss the mechanism underlying bacterial resistance towards co-trimoxazole?
A: Trimethoprim is an antibiotic drug used against bacterial infections. It is also known by another…
What exactly are prodrugs? How do enzyme inhibition and induction impact the therapeutic action of a prodrug?
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- What is the mechanism of chymotrypsin catalysed by enzymes without cofactors?categorize the following into reversible or irreversible (competitive or non-competitive) inhibitors. No explanation is required, just list the name of the inhibitor. a) Penicillin b) Cyanide c) Aspirin d) TipranavirWhat is Chemoattractants?
- . Based on what you know about enzyme inhibition, classify the following examples as irreversible, competitive, or noncompetitive enzyme inhibition. A) competitive B) noncompetitive C) irreversible 1) Diisopropyl fluorophosphate binds to acetylcholinesterase and permanently inactivates the enzyme. Paralysis results. 2) A drug binds to the active site of an enzyme but disassociates and leaves the enzyme active. 3) A toxin binds to the surface of an enzyme. The enzyme then binds the substrate, but no product is produced. The toxin may disassociate and the enzyme will become active again. 4) Vitamin K is a coenzyme involved in blood clotting. An anticoagulant drug binds at the site of vitamin K bonding, blocking vitamin K binding and preventing clotting. Clotting resumes after the patient stops taking the drug. 5) Aspirin binds to prostaglandin synthetase and permanently stops its ability to produce prostaglandin.What are oligonucleotide drugs?Why are uncompetitive and mixed inhibitors generally considered to be more eff ective in vivo than competitive inhibitors?
- How are affinity labels and suicide inhibitors different from group specific covalent modifieres (in terms of irreversible inhibition)?Explain the importance of Stemoamide ?For a weak ester drug that is unstable in highly acidic or alkaline solutions, what strategies could be used to make this drug more bioavailable after oral administration?