What are oligonucleotide drugs?

Principles Of Radiographic Imaging: An Art And A Science
6th Edition
ISBN:9781337711067
Author:Richard R. Carlton, Arlene M. Adler, Vesna Balac
Publisher:Richard R. Carlton, Arlene M. Adler, Vesna Balac
Chapter40: Nuclear Medicine And Molecular Imaging
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What are oligonucleotide drugs?

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oligonucleotide drugs or Antisense oligonucleotides are are a short stretch of single stranded DNA or RNA that is often complementary to an infectious mRNA or disease mRNA that is made during the time of infirmity.

these antisense molecules hybridise with the target mRNA and prevent translation by degrading the antisense oligo-target mRNA hybrid by RNase H.

chemically-modified antisense oligonucleotides are often used in the therapy and they are taken up the cell by receptor-mediated endocytosis.

Antisense oligonucleotides are currently used in many life threatening diseases like

  1. cancers
  2. Batten disease
  3. CMV retinitis
  4. Duchenne muscular dystrophy
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