Verizon 7:17 PM 46% X Chap 13 Fall 2019.pptx 1 2 1 3 |-1 1-2 1l-1 I1-2 I-3 ll-4 1250 Northern blot nt 1020 o2010 Pearson Edion n

Health Safety And Nutrition F/Young Child
9th Edition
ISBN:9781305144767
Author:MAROTZ
Publisher:MAROTZ
Chapter5: The Infectious Process And Environmental Control
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A hereditary disease is inherited as an autosomal recessive trait. The wild-type allele of the disease gene produces a mature  mRNA that is 1250 nucleotides (nt) long. Molecular analysis shows that the mature mRNA consists of four exons that measure 400 nt (exon 1), 320 nt (exon 2), 230 nt (exon 3), and 300 nt (exon 4). A mother and father with two healthy children and two children with the disease have northern blot analysis performed. The results of the northern blot for each family member are shown below. 

a) Identify the genotype of each family member, using the size of mRNAs to indicate each allele. (For example, a person who is homozygous wild type is 1250/1250). 

b) Based on your analysis, what is the most likely molecular abnormality causing the disease allele? 

Verizon
7:17 PM
46%
X
Chap 13 Fall 2019.pptx
1
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1
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|-1
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1l-1
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1250
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1020
o2010 Pearson Edion n
Transcribed Image Text:Verizon 7:17 PM 46% X Chap 13 Fall 2019.pptx 1 2 1 3 |-1 1-2 1l-1 I1-2 I-3 ll-4 1250 Northern blot nt 1020 o2010 Pearson Edion n
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