Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Using the figure shown below, briefly explain the relationship between levels of HIV viral RNA, levels of CD4+ T cells, and health of the infected human.

Primary
Infection
Death
1200
Acute HIV Infection
1000
107
Anti-HIV immune
Opportunistic
Infections
responses
800
Clinical Latency
106
600
Onset of
Symptoms
105
400-
104
AIDS
200
103
102
12
3
6
9
12
4
8
10
Weeks
Years
Time after infection
FIGURE 5.15 Typical time course of HIV infection and progression to disease. Patterns of CD4+ T-cell
decline and virus load vary greatly among patients. See also Fig. 5.16 for mortality as a function of initial viral
load. Some case definitions for AIDS specify a CD4+ count below 200 cells/µl (horizontal line). [From Coffin
et al. (1997, Fig. 5, p. 600).]
CD4+ T-cells (cells/ul)
HIV RNA (Copies/ml plasma)
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Transcribed Image Text:Primary Infection Death 1200 Acute HIV Infection 1000 107 Anti-HIV immune Opportunistic Infections responses 800 Clinical Latency 106 600 Onset of Symptoms 105 400- 104 AIDS 200 103 102 12 3 6 9 12 4 8 10 Weeks Years Time after infection FIGURE 5.15 Typical time course of HIV infection and progression to disease. Patterns of CD4+ T-cell decline and virus load vary greatly among patients. See also Fig. 5.16 for mortality as a function of initial viral load. Some case definitions for AIDS specify a CD4+ count below 200 cells/µl (horizontal line). [From Coffin et al. (1997, Fig. 5, p. 600).] CD4+ T-cells (cells/ul) HIV RNA (Copies/ml plasma)
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