Use the information uploaded in the picture to help with this question.Would you conclude that IP-1383 induces mutations or not? Briefly (one or two sentences) explain how or why you came to your conclusion. 5) One very common way to do a preliminary test for whether or not a compound (a new drug, a sunscreen, an artificialsweetner, whatever) causes mutations, before doing toxicity testing in cultured cells or mice, involves using E. coli thathave lost the ability to synthesize the amino acid histidine for themselves. These his E. coli grow just fine as long as thegrowth medium they are cultured on contains histidine, but if they are cultured on medium that does not containhistidine, they will rapidly die due to lack of that essential amino acid. This is called the Ames test, after the scientist,Bruce Ames, who developed it.To test the mutagenic properties of IP-1383, a novel derivative of ibuprofen being analyzed as a potential anti-inflamatory drug for the treatment of rheumatoid arthritis, his E. coli were incubated in an aqueous solution of IP-1383for 4 hours and then plated on growth medium that did not contain histidine. As a control, genetically identical his¨ E.coli were incubated in sterile water and plated on the same growth medium. To test whether or not IP-1383 is toxic to E.coli cells, another sample of the his E. coli that were incubated in IP-1383 were plated on growth medium thatcontained histidine. After the E. coli were allowed to grow and form colonies on the growth medium for 18 hours, thenumber of colonies on each plate was counted and the following results were obtained:# of colonies on# of colonies onTreatmentmedium with histidinemedium without histidineIP-13838,986201sterile water9,01119

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Uploaded: 2024-03-20T06:42:41.000Z
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Description: Use the information uploaded in the picture to help with this question.Would you conclude that IP-1383 induces mutations or not? Briefly (one or two sentences) explain how or why you came to your conclusion. 5) One very common way to do a preliminar