1. Use the info of this molecule as well as the attached addendum to demonstrate the flow of genetic information to protein sequence as described by the so-called “Central Dogma” . Clearly indicate the direction of your polynucleotide strands and peptide/protein. ATG GCA TGC AAT AGC TCA TGC2. What would happen to the amino acid sequence if the underlined nucleotide (C) would change to an A? TABLE 30.1 The Genetic CodeFirstThirdThird-Base Degeneracy Is Color-CodedPositionSecondPosition(5'-end)Position(3'-end)Third BasesThird-Basewith SameAGRelationshipMeaningNumber of CodonsUAU Tyr| Third baseU, C, A, G 32 (8 families)UUU PheUCU SerUGU CysUGC CysUGA StopUGG TrpUUUC PheUCC SerirrelevantUAC TyrUAA StopUAG StopCUUUA LeuUCA SerAA or G12 (6 pairs)PurinesUUG LeuUCG SerGPyrimidinesU or C14 (7 pairs)CCU ProССС РrоCCA ProCGU ArgCGC ArgCGA ArgCGG ArgCUU LeuCAU HisThree outU, C, A3 (AUX = Ile)CUC LeuCAC Hisof fourCCUA LeuCAA GlnAG onlyUniquedefinitions2 (AUG = Met)(UGG = Trp)CUG LeuCCG ProCAG GlnGAUU IleACU ThrAAU AsnAGU SerUUniqueA only1 (UGA = Stop)AUC IleACC ThrAAC AsnAGC SerCdefinitionАAA LysAAG LysAGA ArgAGG ArgAUA IleACA ThrAAUG Met*ACG ThrGGAU AspGAC AspGGU GlyGGC GlyGGA GlyGUU ValGCU AlaUGUC ValGCC AlaCGGUA ValGCA AlaGAA GluAGUG ValGCG AlaGAG GluGGG GlyG

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Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

1. Use the info of this molecule as well as the attached addendum to demonstrate the flow of genetic information to protein sequence as described by the so-called “Central Dogma” . Clearly indicate the direction of your polynucleotide strands and peptide/protein.

ATG GCA TGC AAT AGC TCA TGC

2. What would happen to the amino acid sequence if the underlined nucleotide (C) would change to an A?

TABLE 30.1 The Genetic Code
First
Third
Third-Base Degeneracy Is Color-Coded
Position
Second
Position
(5'-end)
Position
(3'-end)
Third Bases
Third-Base
with Same
A
G
Relationship
Meaning
Number of Codons
UAU Tyr
| Third base
U, C, A, G 32 (8 families)
UUU Phe
UCU Ser
UGU Cys
UGC Cys
UGA Stop
UGG Trp
U
UUC Phe
UCC Ser
irrelevant
UAC Tyr
UAA Stop
UAG Stop
C
U
UUA Leu
UCA Ser
A
A or G
12 (6 pairs)
Purines
UUG Leu
UCG Ser
G
Pyrimidines
U or C
14 (7 pairs)
CCU Pro
ССС Рrо
CCA Pro
CGU Arg
CGC Arg
CGA Arg
CGG Arg
CUU Leu
CAU His
Three out
U, C, A
3 (AUX = Ile)
CUC Leu
CAC His
of four
C
CUA Leu
CAA Gln
A
G only
Unique
definitions
2 (AUG = Met)
(UGG = Trp)
CUG Leu
CCG Pro
CAG Gln
G
AUU Ile
ACU Thr
AAU Asn
AGU Ser
U
Unique
A only
1 (UGA = Stop)
AUC Ile
ACC Thr
AAC Asn
AGC Ser
C
definition
АAA Lys
AAG Lys
AGA Arg
AGG Arg
AUA Ile
ACA Thr
A
AUG Met*
ACG Thr
G
GAU Asp
GAC Asp
GGU Gly
GGC Gly
GGA Gly
GUU Val
GCU Ala
U
GUC Val
GCC Ala
C
G
GUA Val
GCA Ala
GAA Glu
A
GUG Val
GCG Ala
GAG Glu
GGG Gly
G

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