Thyroid peroxidase iodinates tyrosine residues within the thyroglobulin protein, and this enzymatic reaction occurs in the cytoplasm of follicular cells of the thyroid gland.  True  False.

Explain how vinclozolin acts as an endocrine disrupter.

Give an overview of the pathway and what it does, and explain the nature of the TNF ligand and the receptor for that ligand. Make sure to include an explanation of the proteolytic and phosphorylation cascades.

Explain the activation of the protein kinase, c-raf, in response to growth factor receptor activation

Please explain the steps in this pathway on the picture.

Give correct typing answer with explanation

Herceptin is an antibody that is used to treat certain forms of breast cancer by binding to a class of estrogen receptors. What is the basis for its effectiveness in treating certain forms of breast cancer?

Describe a mechanism by which a steroid hormone might act to increase intracellular levels of cyclic AMP. Match the words in the left column to the appropriate blanks in the sentences on the right. activate decrease inhibit repressed induced increase Reset Help Since steroid hormone-receptor complexes specific genes, a steroid hormone could in principle transcription of the gene for adenylate cyclase and, hence, steady-state level of this enzyme. Other possibilities could include synthesis of a phosphodiesterase inhibitor or synthesis of cAMP phosphodiesterase. the transcription of the

Match the following to the appropriate receptor pathway: Vitamin D Receptor Choose... Heat Shock Protein (HSP) Choose... Growth Factor Receptor Steroid Receptor Family Adenylyl Cyclase (AC) GPCR Thyroid Receptor Family Cytokine Receptor Tyrosine Kinase Domain JAK/STAT Choose... NFKB Choose... G protein Choose... DAG/IP3 pathway Choose...

Dominant mutations in the Akt gene have been identified that lead to gain- of-function phenotypes. In these children, the Akt protein has a E17K mutation, which results in the Akt protein being phosphorylated by PDK1 in the absence of insulin signaling. It is observed in these patients that the GRB2 pathway is also activated in the absence of insulin. Predict two symptoms in these patients resulting from activation of insulin signaling in the absence of insulin. Prefix definitions; hypo= below, hyper = above. 1) Severe fasting hyperglycemia, 2) Abnormal tissue hypergrowth 1) Insulin resistance in muscle, 2) Abnormal tissue hypergrowth 1) Severe fasting hypoglycemia, 2) Abnormal tissue hypogrowth 1) Severe fasting hyperglycemia, 2) Defect in insulin secretion 1) Severe fasting hypoglycemia, 2) Abnormal tissue hypergrowth