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Three human genomic DNA fragments (A, B, and C) are sequenced and revealed the following: fragment A contains gene 2 and 3; fragment B contains gene 2 and 4; fragment C contains gene 1 and 4; Based on this, what should the order of the three DNA fragments in a sequencing contig?

Three human genomic DNA fragments (A, B, and C) are sequenced and revealed the following: fragment A contains gene 2 and 3; fragment B contains gene 2 and 4; fragment C contains gene 1 and 4; Based on this, what should the order of the three DNA fragments in a sequencing contig?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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The image features a multiple-choice question with five possible answer options. The options are listed in a vertical format with radio buttons beside each one, indicating that only one selection can be made at a time. The text appearing in the image is as follows: - O B-C-A - O cannot be determined - O C-B-A - O C-A-B - O A-C-B
Transcribed Image Text:The image features a multiple-choice question with five possible answer options. The options are listed in a vertical format with radio buttons beside each one, indicating that only one selection can be made at a time. The text appearing in the image is as follows: - O B-C-A - O cannot be determined - O C-B-A - O C-A-B - O A-C-B
**Understanding Sequencing Order of DNA Fragments** In genomic research, understanding the sequence of DNA fragments is crucial for comprehending genetic structures and functions. Below is a scenario presented for educational purposes that delineates this process: **Problem Statement** Three human genomic DNA fragments (A, B, and C) are sequenced and reveal the following information: - Fragment A contains gene 2 and 3; - Fragment B contains gene 2 and 4; - Fragment C contains gene 1 and 4; **Question:** Based on this data, what should be the order of the three DNA fragments in a sequencing contig? **Options:** - A) B-C-A - B) Cannot be determined - C) C-B-A To deduce the sequence, consider which genes overlap among the fragments and how they might align: 1. **Fragment A (2, 3)**: Overlaps with Fragment B, since both share gene 2. 2. **Fragment B (2, 4)**: Overlaps with Fragment C, since both share gene 4. 3. **Fragment C (1, 4)**: Starts with a unique gene (1), which should likely be at the beginning of the sequence. **Analysis**: - Aligning Fragment C and Fragment B through the common gene 4 order would place Fragment C before Fragment B. - Aligning Fragment B and Fragment A through the common gene 2 positions Fragment B before Fragment A. Thus, the sequence order is: **C-B-A** By identifying and sequencing the overlapping genes, the logical order of the DNA fragments is determined, assisting in the comprehension and mapping of genetic information. This educational exercise showcases the critical thinking and analysis involved in genomic sequencing.
Transcribed Image Text:**Understanding Sequencing Order of DNA Fragments** In genomic research, understanding the sequence of DNA fragments is crucial for comprehending genetic structures and functions. Below is a scenario presented for educational purposes that delineates this process: **Problem Statement** Three human genomic DNA fragments (A, B, and C) are sequenced and reveal the following information: - Fragment A contains gene 2 and 3; - Fragment B contains gene 2 and 4; - Fragment C contains gene 1 and 4; **Question:** Based on this data, what should be the order of the three DNA fragments in a sequencing contig? **Options:** - A) B-C-A - B) Cannot be determined - C) C-B-A To deduce the sequence, consider which genes overlap among the fragments and how they might align: 1. **Fragment A (2, 3)**: Overlaps with Fragment B, since both share gene 2. 2. **Fragment B (2, 4)**: Overlaps with Fragment C, since both share gene 4. 3. **Fragment C (1, 4)**: Starts with a unique gene (1), which should likely be at the beginning of the sequence. **Analysis**: - Aligning Fragment C and Fragment B through the common gene 4 order would place Fragment C before Fragment B. - Aligning Fragment B and Fragment A through the common gene 2 positions Fragment B before Fragment A. Thus, the sequence order is: **C-B-A** By identifying and sequencing the overlapping genes, the logical order of the DNA fragments is determined, assisting in the comprehension and mapping of genetic information. This educational exercise showcases the critical thinking and analysis involved in genomic sequencing.
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