Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in the body's tissues. Research has described many causes for the condition that results in different patterns of inheritance. Here is what we know of the family members: (no other information is provided) II II IV V VI A) Based on the information presented, what is the most likely mode of inheritance? In own words, explain your reasoning. your B) What are the chances that V-6 and V-7 have an afflicted child? C) What are the chances that VI-9 and VI-10 have a HFTC afflicted child?

Tell me whether it is autosomal reccessive inheritance,autosomal domiant inheritance,sex-linked reccessive inheritance, sex-linked dominay inheritance or y-linked inheritance.

Hemophilia, disease in which the blood lacks a clotting factor, is caused by an X linked recessive gene. Joe doe not have hemophilia and Lucille is heterozygous for the condition.  What is the chance that their MALE child will have hemophilia? (Note: you are calculating the probability for their MALE children only, in other words if they have 1 male child, what is the probability that he will be born with the disease?)     0%     1/4 or 25%     2/4 or 50%     3/4 or 75%     4/4 or 100%

Faulty Tooth Enamel Formation Amelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is notexpressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI: A boy was born without amelogenesis imperfecta A girl was born without amelogenesis imperfecta  A boy was born with severe amelogenesis imperfecta A boy was born with non severe amelogenesis imperfecta   Identify the parental genotypes.  Complete the Punnett square for the parental…

A defective gene on chromosome 15 causes Tay-Sachs disease. It is a central nervous system neurodegenerative disease that most often affects infants, though older children and adults can have late-onset forms of the disease. The defective gene prevents the body from making a protein called hexosaminidase A. Without, hexosaminidase A, chemicals called gangliosides build up in the nerve cells of the brain, destroying brain cells. Pedigree information regarding the incidence of Tay-Sachs within a family is depicted above. The row below that indicates the genotypes of individuals II-1, II-2, and III-1 is Select one: a. II-1 II-2 III-1 Aa Aa aa b. II-1 II-2 III-1 XAY XAXa XAXa c. II-1 II-2 III-1 XAY XAXA XaXa d. II-1 II-2 III-1 AA aa Aa

Marfan syndrome is an autosomal dominant disorder caused by mutations in the FBN1 gene. It affects connective tissues, commonly resulting in long bones, abnormal curvature of the spine, defects in the eye (glaucoma), and faulty heart valves.X-linked hypophosphatemia is an X-linked dominant disorder that causes a type of rickets. Which of the following rows describes the inheritance pattern of these disorders? Select one: a. Marfan Syndrome X-linked Hypophosphatemia Males are affected more frequently than females. Female carriers can pass on the trait to their sons. b. Marfan Syndrome X-linked Hypophosphatemia Males and females are affected with equal frequency. Affected males can only pass on the trait to their daughters. c. Marfan Syndrome X-linked Hypophosphatemia Affected males can only pass on the trait to their daughters. Males and females are affected with equal frequently. d. Marfan Syndrome X-linked Hypophosphatemia Female carriers can…

If individuals II-5 and II-4 have another child, the probability of this child having the polydactyly trait is ___%.

Answer the following questions given the pedigree below. Please assume that no other mutations are occurring, complete penetrance, and that the individual marked with an asterisk (*) doesn’t carry the allele causing the affected phenotype. Q2) What are the genotypes of the following individuals listed in the table below. Use the uppercase “A” to represent the dominant allele and lowercase “a” for the recessive allele. Individual All possible genotypes I-2   II-1   IV-2   V-2   II-2   II-3

How many males have hemopilia? (refer to image).