A man and both his parents are affected with a disease. His older brother is unaffected. This man marries a woman who is unaffected with this disease. Her father and her younger brother are affected with the same disease, but her mother and youngest brother are unaffected. Assume that this disease is caused by a single gene with two alleles with complete dominance. a. Draw the pedigree of the family above using the correct symbols and numbering.  b. What is the chance that the couple will produce an unaffected child? Please show your calculations.

Consider a situation where you have a parental cross with the mother and father phenotypes listed below The counts of the F1 offspring are listed in Table 1. Two randomly selected individuals are selected and mated to produce a set of F2 individuals. If you test the F2 counts to determine whether they are consistent with an autosomal dominant mode of inheritance, what is your decision? Use a 0.05 significance level. PARENTAL CROSS Parental cross: Mother with disease phenotype, Father with wild-type phenotype. Table 1. F1 DATA Gender   Phenotype       Disease Wild-Type Male   0 23 Female   0 34 Table 2. F2 DATA Gender   Phenotype       Disease Wild-Type Male   7 25 Female   0 25 a) Do not reject the null hypothesis that the F2 data are consistent with an autosomal dominant mode of inheritance; chi-square goodness of fit test p-value is greater than 0.05. b) Do not reject the null hypothesis that the F2 data are consistent with an autosomal dominant mode of…

Given the pedigree below, answer the following questions. Note that filled symbols represent affected individuals. You assume that the allele carrying the disease is rare and therefore individuals marrying into the family are unlikely to have defective alleles. Also, assume complete penetrance. Q2) What are the genotypes of the following individuals listed in the table below? Use the uppercase “A” to represent the dominant allele and lowercase “a” for the recessive allele. Individual Genotype II-7   III-5   IV-1   IV-3   I-2   III-7

Below is a pedigree chart for a family that has a history of Alkaptonuria.   Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications.  Given this pedigree answer the following questions.   Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3?  If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype?  Why or why not?

In alley cats, the coat color is determined by a gene carried on the X-chromosome. At the same time, the alleles are expressed as intermediate (incomplete-dominance) inheritance. Genotypes and color are as follows: Females: X ^ b * X ^ b =yellow X^ B X ^ b = calico X ^ B * X ^ B =black Males: X ^ y * Y =yellow X ^ B * Y=bhck (a) A black cat has a litter of seven kittens: three black males, one black female and three calico females. Comment on the probable paternity of this litter and explain.

In this figure, the black circles and squares indicate a genetic disease. Males are represented by squares, females by circles. A. Based on the pedigree in the image, does this gene appear to be inherited in a dominant or recessive manner? Explain your prediction. B. Use the letter B to indicate a diseased allele and the letter b to indicate a normal allele. Predict the genotype of the married female child in generation II. Justify your prediction. C. If the female in generation II has a second child, what is the chance that this child will inherit the disease? Explain.

The shape of a heliodor is an X-linked trait. Male heliodors inherit two X chromosomes, while the females inherit an X and a Y chromosome. The recessive allele codes for the common bell-shape  while the dominant phenotype is a round shape . Hudson is a round male and has offspring with Heidi, a bell-shaped female. They already have one daughter, Hannah, who is shaped like her mother. The reason for your answer above is:   a.Females heliodors inherit two X chromosomes, so it is less likely they would only inherit two recessive alleles for being bell-shaped.   b.Males heliodors inherit two X chromosomes, so it is less likely they would only inherit two recessive alleles for being bell-shaped.   c.Males only need to inherit one recessive allele to be bell-shaped.   d.Being male or female has no impact on the shape of a heliodor

Determine what is the most likely mode of inheritance of this disease (whether it is inherited as the result of an X-linked dominant or X-linked recessive trait). Use "A" for the allele associated with the dominant phenotype, and lowercase "a"" for the allele associated with the recessive phenotype. Write the most probable genotype for each individual based on the mode of inheritance you have determined. Show how all the partners are crossed and the expected offspring produced (You may use Punnett Square). OT I OT do II

You are trying to find a blood donor to help treat some of your patients. The C-yonce and Kay-Z have 3 children with blood types A , B, and O. The youngest with blood type O needs a transfusion and you're trying to figure out if either of the parents are a match so you test the parent genotypes. Note: Alleles for each blood type are expressed as follows: blood type A= I^A blood type B= I^B blood type O= i Hint: Remember that 2 alleles contribute to a persons blood type. Pay attention to dominant and recessive relationships among the alleles.     1-C-yonce is type B. What must her genotype be? 2-What must Kay-Z’s genotype be? 3-Which parent can give blood to their child ? 4-After running lab tests, it was discovered that the children's blood types were reported incorrectly.(This does not affect the genotypes entered for C-yonce and Kay-Z in the previous questions.) Their youngest actually has blood type AB, and still needs a blood transfusion.  Which parent can donate blood to the child…

The pedigree above shows inheritance of inability to taste PTC (shaded individuals cannot taste it), which is caused by mutation in a single gene. What is the probability that III-3 and III-4 will have a child who is heterozygous?     1   1/3   1/9   4/9   1/4   3/4   1/2   2/3   1/16