The following pedigree represents the inheritance pattern of a specific genetic trait in humans. Assume the trait is common in the population. This disorder could be inherited in which of the following ways? as an Autosomal Recessive trait as both an Autosomal Recessive trait and an X-linked recessive trait Ob. as an Autosomal Dominant trait Oc. as an X-linked recessive trait Od.
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- QUESTION 10 Consider the following pedigree. With no other information provided, what is the most likely mode of transmission (or mode of inheritance) of the allele for the unusual trait? autosomal dominant sex-linked recessive autosomal recessive O sex-linked dominantQUESTION 22 Consider whether the mode of inheritance for each of the pedigrees below is autosomal dominant or autosomal recessive Pedigree I Both pedigrees show autosomal dominant modes of inheritance Pedigree I is autosomal dominant while pedigree II is autosomal recessive O Pedigree I is autosomal recessive while pedigree II is autosomal dominant O Both pedigrees show autosomal recessive modes of inheritance QUESTION 23 A Pedigree II The pedigree below shows the inheritance of an X-linked recessive disorder. B TH QuersGenetic Inheritance Patterms Retinitis pigmnentosa (RP) can be autosomal recessive, autosomal dominant, or x-linked. Apparently the dominant forms are often less severe. Eric's form of RP is Usher's Syndrome, which is an autosomal recessive inheritance (i.e., you must get a copy of the defective gene from your Mom and one from your Dad). Autosomal means it is not carried on one of the chromosomes that determines sex. Usher's Type II is recessive, so for Eric this means that both his Mom and Dad are carriers of this condition. His brother, Dirk, does not have any symptoms of RP. Question below - short answer approach Imagine you are a genetics counselor, and Dirk, Erik's brother, comes in to see you. Based on his parents, what are Dirk's possible genotypes for RP? What advice would you give Dirk about the chances of Dirk's children having retinitis pigmentosa if his wife is not a carrier? How would your advice change if his wife fully has the disease? Describe all the possibilities,…
- Analysis of X-Linked Dominant and Recessive Traits Suppose a couple, both phenotypically normal, have two children: one unaffected daughter and one son affected with a genetic disorder. The phenotype ratio is 1:1, making it difficult to determine whether the trait is autosomal or X-linked. With your knowledge of genetics, what are the genotypes of the parents and children in the autosomal case? In the X-linked case?Analysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic disorder in a family, you are able to collect a four-generation pedigree that details the inheritance of the disorder in question. Analyze the information in the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedGenetic Inheritance Patterms Retinitis pigmentosa (RP) can be autosomal recessive, autosomal dominant, or x-linked. Apparently the dominant forms are often less severe. Eric's form of RP is Usher's Syndrome, which is an autosomal recessive inheritance (i.e., you must get a copy of the defective gene from your Mom and one from your Dad). Autosomal means it is not carried on one of the chromosomes that determines sex. Usher's Type II is recessive, so for Eric this means that both his Mom and Dad are carriers of this condition. His brother, Dirk, does not have any symptoms of RP. Draw a pedigree of Eric's family showing possible genotypes and chances of having RP. Your pedigree must include his parents, Eric, his brother Dirk, and a potential daughter of Eric's. Draws a pedigree that shows the correct genotypes and chances of having retinitis pigmentosa for Eric and his family. D.Focus (United States) a S W 37 F 八 口
- TOPIC: Sex-linked inheritance Glucose-6-phosphate dehydrogenase deficiency/G6PDD (g) is an X-linked recessive condition wherein the red blood cells of affected individuals undergo premature hemolysis. Fragile X syndrome (F), on the other hand, is an X-linked dominant mutation characterized by a mild to moderate intellectual disability. Amelogenesis imperfecta (AMELY) (A) is a sex-linked congenital disorder affecting the formation of the teeth enamel making affected individuals at higher risk for dental cavities and related problems. Only male offspring inherit this condition. Jane is heterozygous for both X-linked traits like her mother. Her father is normal for both X-linked traits. James has a mother who suffers from G6PDD but not from fragile X-syndrome. His father does not exhibit any X-linked disorder but has amelogenesis imperfecta. What are the genotypes of the following: Jane: ________ James: _________ Jane’s mother: __________…QUESTION 5. The pedigree below follows the appearance of a rare autosomal dominant condition resulting in malformation of limbs through a family. What is the penetrance of this trait? i.e., What is the ratio between the number of individuals in the pedigree who display the trait (numerator) and the number of individuals you know from the pedigree must have the trait-determining genotype (denominator)? Enter your answer in the form of a fraction without any spaces. e.g., If your answer is “one-fourth”, enter: 1/4tion 8: below is the pedigree of inheritance of phenylketonuria (PKU). We will designate the letter Caven for the dominant allele and "p" for the recessive allele. 4 The pedigree shows that the pattern of inheritance for the allele for phenylk ylketonuria is: I. II. 1 III. IV. Autosomal dominant Autosomal recessive X-linked dominant X-linked recessive b. The parents in generation I have how many children: I. 3 Boys II. 3 Girls III. IV. 3 Boys and 1 Girl 3 Girls and 1 Boy c. What is the genotype of individual 1 in generation III: I. PP II. pp III. Pp " O 1 III. 50% E III 1 ▬ 2 2 IV. 25% 1 3 IV. Can be PP or Pp ii. Suppose that a man having type AB blood marries a woman having type O blood. What is the probability that their child will have type A blood? I. 100% II. 75% 2 4 3
- PART 3– Sex Linkage Hemophilia is a recessive sex-linked disorder in which an important clotting factor protein (Factor VIII) is not produced in a functional form. Queen Victoria was a carrier of the recessive Factor VIII allele, meaning she carried the allele but was asymptomatic. Recently, historians have discovered that she secretly had an affair with the Austrian Count Chocula, who, unbeknownst to her, was a hemophiliac. Naturally, the Royal Family fought to have this information suppressed, but it was revealed that they had many children together. 1. Using the correct allele notation, write the genotypes for Queen Victoria and Count Chocula. 2. In the Punnett Square below, show the cross between the Queen and the Count. P> PĮA DNA variant has been found linked to a rare autosomal dominant disease in humans and can thus beused as a marker to follow inheritance of the diseaseallele. In an informative family (in which one parentis heterozygous for both the disease allele and the DNA marker in a known chromosomal arrangementof alleles, and his or her mate does not have the samealleles of the DNA variant), the reliability of such amarker as a predictor of the disease in a fetus is related to the map distance between the DNA markerand the gene causing the disease.Imagine that a man affected with the disease(genotype Dd) is heterozygous for the V1and V2forms of the DNA variant, with form V1on the samechromosome as the D allele and form V2on the samechromosome as d. His wife is V3V3dd, where V3isanother allele of the DNA marker. Typing of the fetusby amniocentesis reveals that the fetus has the V2andV3variants of the DNA marker. How likely is it thatthe fetus has inherited the disease allele D if thedistance…QUESTION 4 Look at the pedigree below. Which mode(s) of inheritance could explain this? Select all that apply. OY-linked O X-linked recessive O autosomal recessive O x-linked dominant O autosomal dominant O mitochondrial