® Huntington's Disease is a rare neurodegenerative disorder caused by a defective gene. A pedigree is shown below with a family that is affected. Describe the pattern of inheritance that Huntington's Disease is following. Justify your answer with reference to the diagram. Use proper notation (II-3, etc.) when referring to individuals. 2 II 2 3 6 7 1 2 3 4 5 00
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- If diseases such as cardiovascular disease (hypertension and atherosclerosis) are familial, is this an indication that there is a genetic contribution to these traits? What would you do to confirm that genetics is involved in this condition?Why do unrelated children with a disorder such as Down syndrome resemble each other more closely than they do their siblings?Does the phenotype indicated by the red circles and squares in this pedigree show an inheritance pattern that is autosomal dominant, autosomal recessive, or X-linked?
- Given the karyotype shown at right, is this a male or a female? Normal or abnormal? What would the phenotype of this individual be?The following pedigree shows the inheritance of a rare genetic disorder. Determine the most likely mode of inheritance, and for exam practice (unmarked on the assignment) write a clear justification for your conclusion. Remember that some pedigrees don't provide sufficient data/information to discriminate between possibilities. If that is the case, select all the possible answers. I III Tb 2 3 1 1 3 autosomal dominant autosomal recessive Osex-linked dominant Osex-linked recessive O 2 HShown above is a family pedigree tree in which family members afflictedwith the disease Haemophilia are shown with filled-in squares (male) or circles (females). A couple is trying to determine the likelihood of passingon the disease to their future children (represented by the ? symbolabove) because the hemophilia runs in the woman’s family. Turner syndrome is a disease in which an individual is bornwith only a single X chromosome. Suppose the woman in thecouple is a carrier for hemophilia and has a child with Turnersyndrome. Would this child have the disease?
- O Huntington's Disease is a rare neurodegenerative disorder caused by a defective gene. A pedigree is shown below with a family that is affected. Describe the pattern of inheritance that Huntington's Disease is following. Justify your answer with reference to the diagram. Use proper notation (II-3, etc.) when referring to individuals. II 2 3 6 8 II 1 2 3 4 5 7.Neurofibromatosis-1 (NF1) is an autosomal dominant disorder where tumours form in the base layer of the skin or in nerve tissues. What is the probability that individuals II-1 and II-2 will have a genetic son with NF1? Find the image attached.Refer to the pedigree below which shows inheritance for achondroplasia (dwarfism), a dominantly inherited trait (denoted as D), which are the darkened circles and squares. Dwarfism (darkened shapes) are dominantly inherited, while normal height is recessively inherited (hh). Based on the pedigree, what is the correct genotype for individual #II-6? Dominant Autosomal Pedigree 2 II 2 3 II 1 2 3 6 9 10 Dd DD DD or Dd dd
- Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele unless otherwise indicated. Assume complete penetrance. I II 5 6 III 6 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Provide a genotype for individual III-6 for the most likely mode of inheritance as determined in (a).A typical pedigree for a family that carries neurofibromatosis is shown below. Note that carriers are not indicated with half-colored shapes in this chart. Use the letter "N" to indicate the dominant neurofibromatosis allele, and the letter "n" for the normal allele. Use the below pedigree chart and your knowledge on how to interpret a pedigree chart to answer questions # 7-9. 1 Nn nn nn 3 nn 7. Is individual #1 most likely homozygous dominant or heterozygous? Explain how you can tell. 8. What is the genotype of individual #2? Explain how you can tell. 9. What is the genotype of individual #3? Explain how you can tell. 2)152 Phenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. Answer the following questions in order and show solutions whenever relevant. If they have a normal child, what is the probability that he or she will be heterozygous? If they have three children, what is the probability of having 2 affected children and one normal child?