Telomere shorting is related to aging. Telomerase can extend telomeres. Why do we not just figure out how to turn telomerase on in all of our cells so that we can live forever?

If the following nucleotide sequence, CTC/TGT/AAG/ACC/TTT experienced a mutation resulting in the deletion of the second cytosine in the first DNA triplet so the sequence is now CT_/TGT/AAG/ACC/TTT, what would be the amino acid sequence created from this mutated DNA strand? Table of mRNA codons UUA, UUG = leucine AGG, AGA = arginine %3D CAU, CAC = histidine GUU, GÜC, GUA = valine GAA. GAG=glutamic acid GCU, GUA, GUG = alanine GAU, GAC = asparagine GGU, GGC, GGA = glycine UCA, UCU =serine CGU, CGC, CGA = arginine

Another cancer cell line that you are working on came from a patient in your medical clinic. You recognize that this is a new type of breast cancer that has never been described before. a. How could you use sequence analysis to determine if this patient inherited the mutation from one of her parents or if it spontaneously occurred in her cells? (Unfortunately her parents have passed away.) b. How could you use sequence analysis to determine if this gene is a tumor suppressor or an oncogene? (For partial credit briefly define tumor suppressor and oncogene.)

You discover a histone variant that has more positive charge than conventional histone proteins. What effect do you predict this histone variant would have when it is inserted into chromatin? A decrease in the strength of histone-DNA interaction, making chromatin less condensed and increasing gene expression An increase in the strength of histone-DNA interaction, making chromatin less condensed and decreasing gene expression An increase in the strength of histone-DNA interaction, making chromatin more condensed and decreasing gene expression O A decrease in the strength of histone-DNA interaction, making chromatin less condensed and decreasing gene expression