T-cell receptor signaling leads to enhanced integrin-mediated cell adhesion. T-Cell Receptor stimulation was shown to affect ICAM-1 (integrin ligand) binding to LFA-1 (integrin) on T cells. To demonstrate this, varying concentrations of purified ICAM-1 were added to unstimulated or T-Cell Receptor-stimulated T cells, and the amount of ICAM-1 binding was measured. The data from such an experiment are displayed on the figure below. Please assign the red or blue lines correctly to ‘unstimulated’ or ‘T-Cell Receptor-stimulated’ T cells, and explain the reasoning for your answer.
T-cell receptor signaling leads to enhanced integrin-mediated cell adhesion. T-Cell Receptor stimulation was shown to affect ICAM-1 (integrin ligand) binding to LFA-1 (integrin) on T cells. To demonstrate this, varying concentrations of purified ICAM-1 were added to unstimulated or T-Cell Receptor-stimulated T cells, and the amount of ICAM-1 binding was measured. The data from such an experiment are displayed on the figure below. Please assign the red or blue lines correctly to ‘unstimulated’ or ‘T-Cell Receptor-stimulated’ T cells, and explain the reasoning for your answer.
Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter5: Abbreviations And Systems Of Measurement
Section: Chapter Questions
Problem 5CRQ
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T-cell receptor signaling leads to enhanced integrin-mediated cell adhesion. T-Cell Receptor stimulation was shown to affect ICAM-1 (integrin ligand) binding to LFA-1 (integrin) on T cells. To demonstrate this, varying concentrations of purified ICAM-1 were added to unstimulated or T-Cell Receptor-stimulated T cells, and the amount of ICAM-1 binding was measured. The data from such an experiment are displayed on the figure below. Please assign the red or blue lines correctly to ‘unstimulated’ or ‘T-Cell Receptor-stimulated’ T cells, and explain the reasoning for your answer.
Transcribed Image Text:SS
108
10-7
108
10-5
104
10-9
Integrin ligand
Ligand binding
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