Tay-Sachs disease (TSD) is a fatal genetic disorder, that results in progressive destruction of the nervous system. Tay-Sachs is caused by a mutation in the gene that codes for an enzyme called hexosaminidase-A (Hex-A). Hex A CDNA from normal and a Tay-Sachs individual was sequenced using the same primer. This is the coding strand and starts in-frame at amino acid position #78. Results are shown below. Read the darkest band in each row. Normal Tay-Sachs (-) ATG C ATG C (+) a. Write each coding strand DNA sequence, normal and Tay-Sachs 5' to 3' b. Write the amino acid sequence that will be translated from each sequence, normal and Tay-Sachs C. Describe the type of mutation? Predict the effect of this mutation on the He> A protein.

Q: Genes with highly similar sequence are often located adjacent one another in the genome. Gene…

A: Linked genes are genes that are tightly placed on the same chromosome and tend to inherit together.…

Q: O a base substitution in an intron 5' splice site O a frameshift in an exon O a missense in an exon…

A: The answer to the question is  A frameshift in exon

Q: A gene contains 30% thymine. What is the percentage of pyrimidines present in this segment? Explain.

A: Purines and pyrimidines are chemical molecules that play a role in the production of DNA and RNA and…

Q: There are dozens of common variations of the c-myc gene, which are associated with different types…

A: The mRNA is produced from the DNA by the transcription process and this mRNA is used for the protein…

Q: In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the…

A: Batten disease is also known as neuronal ceroid lipofuscinoses. Batten disease is an autosomal…

Q: What is the purpose of DNA methylation? Why is it ineffective in the DNA repair of spontaneous…

A: DNA methylation is the process of adding methyl groups to DNA at Nucleotide bases, so that without…

Q: Most laboratory strains of E. coli contain site-specific DNA methylases. The methylase encoded by…

A: Molecular cloning is the process of making identical copies of a DNA molecule, which can be a gene,…

Q: 1. a)What would happen if the aminoacyl tRNA synthetase responsible for charging alanine tRNAs also…

A: The polymerization of amino acids according to the codons on mRNA to form proteins is known as…

Q: The chemical bisulfite transforms cytosine (C) to uracil (U) (U). In DMSO, bisulfite is dissolved.…

A: Dimethyl sulfoxide is an organosulfur compound with the formula (CH₃)₂SO. The chemical bisulfite…

Q: You want to clone the Human Gene A into a plasmid for producing the Protein A in bacteria. GeneA…

A: Introduction :- A plasmid is a small, circular, double-stranded DNA molecule that is separate from…

Q: People with a commonly occurring, wild type allele of PTC with two adjacent thymines at a particular…

A: Part a.) :-ans.The presence of two adjacent thymines at a specific site in the PTC coding sequence…

Q: CpG is an epigenetic term that means: Select one: a. The binding of cytosine with the following…

A: We know that, DNA is the genetic material of almost all living organisms. It is made up of monomers…

Q: After Drosophila DNA has been treated with a restriction enzyme, the fragments are inserted into…

A: a) By preparing a probe using the actin amino acid sequence or using the actin gene sequence known…

Q: Tay Sachs disease is an autosomal recessive disease in which a protein – Hex A - is abnormal. To…

A: Molecular Biology is the branch of biology that deals with a study of the composition, arrangement,…

Q: Extreme UV exposure leads to the SOS response in bacteria. By what mechanism does the SOS response…

A: The SOS response is a DNA damage response mechanism in bacteria that is activated when the cell is…

Q: Which outcome most likely results from exposure of Ogg1 mice to TNFa O A. Increase in cancer…

A: DNA and RNA are biomolecules that carry genetic information between different generations of cells.…

Q: The SARS-CoV-2 genome has a cap at its 5'-end that is the same as the one seen on most human mRNA…

A:

Q: In the Avery, McLeod, McCarty Experiment where supernatant from heat killed, virulent S Strain…

A: Avery, McLeod and McCarty experiment was used to determine the genetic material and its nature on an…

Q: a. Assume that replication has been initiated at that ORI. Provide the sequence of the primer that…

A: DNA is the genetic material of almost all living organisms. It contains information that is…

Q: Oxidation of DNA bases is mutagenic. An oxidized form of guanine,8-oxoguanine, can base-pair with…

A: A base analog has a similar structure to that of a normal base and causes mispairing between bases.…

Q: How many of the mutations listed below would lead to excessive cell growth when the cell was either…

A: Excessive growth occurs when a cell continuously divides and when there is no cell cycle arrest. Myc…

Q: A) Tet-Off B) Tet-On rRTA ITA TRE Target Transgone TRE Target Transgene +Dox +Tc or +Dox tTA ETA TRE…

A: as the diagram shows the tet-on and tet-off system

Q: Based on the following wild type sequence, indicate if each of the mutations should be classified as…

A: Mutations are changes in the sequence of DNA which may or may not affect the phenotype of the…

Q: It has been noted that most transposons in humans and other organisms are located in noncoding…

A: Transposons: Transposons are also referred to as "jumping genes" in which they have the ability to…

Q: THE MOLECULAR GENETICS OF CYSTIC FIBROSIS The following is the base sequence of DNA that codes for…

A: According to our guideline we can answer only first 3 subparts of a question. So, upload rest of the…

Q: Some S. aureus strains can produce an enzyme called beta-lactamase, which breaks down beta-lactam…

A: bacteria have dna as their genetic material .

Q: To identify the following types of genetic occurrences, would acomputer program use sequence…

A: Introduction  With the advancements of Bioinformatics tools and sequencing techniques we can easily…

Q: You sequence the TBX1 gene from patients to diagnose if they have DiGeorge syndrome, and you find…

A: A chromosomal disorder where a small segment of 22 chromosomes is deleted. It is also an…

Q: Would a gain of function mutaion that occurs in the first exon of a gene with twelve exons more…

A: Gain-of-function type of mutation is a mutation in which the altered gene product possesses a new…

Q: A conditional mutation expresses its mutant phenotype only under certain conditions (the restrictive…

A: DNA replication is the process of synthesis of new DNA from the template DNA strand by the enzyme…

Q: A gene contains the sequence CGCATACGGTAC that results in the amino acid sequence arg-ile-arg- tyr.…

A: The translation is a process where a mature mRNA sequence is converted into respective amino acids…

Q: Explain exactly what the X25 probe is and how it allows for visualization of mRNA from the patients.…

A: Frataxin is a mitochondrial protein responsible for iron binding. When the expression of this…

Q: Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which…

A: CF is caused by a mutation in a gene called the cystic fibrosis transmembrane conductance regulator…

Q: The genetic alteration responsible for sickle-cell anemia in humans involves: a transition mutation…

A: sickle cell anaemia is caused by inherited abnormal hemoglobin that causes the sickling of red blood…

Q: Some viruses, such as SV40, contain closed circular DNAs carrying nucleosomes. If the SV40 viral…

A: As we know that viral chromosome is circular in a structure having supercoiled DNA. This…

Q: In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the…

A: CRISPR is a DNA sequence that found in prokaryotic organism's genome like bacteria , archaea.…

Gene Interactions

When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.

Gene Expression

Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.