Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Tay-Sachs disease (TSD) is a fatal genetic disorder, that results in progressive
destruction of the nervous system.
Tay-Sachs is caused by a mutation in the gene that codes for an enzyme called
hexosaminidase-A (Hex-A).
Hex A CDNA from normal and a Tay-Sachs individual was sequenced using the same
primer.
This is the coding strand and starts in-frame at amino acid position #78.
Results are shown below. Read the darkest band in each row.
Normal
Tay-Sachs
(-)
ATG C
ATG C
(+)
a. Write each coding strand DNA sequence, normal and Tay-Sachs 5' to 3'
b. Write the amino acid sequence that will be translated from each sequence,
normal and Tay-Sachs
C. Describe the type of mutation? Predict the effect of this mutation on the Hex
A protein.
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Transcribed Image Text:Tay-Sachs disease (TSD) is a fatal genetic disorder, that results in progressive destruction of the nervous system. Tay-Sachs is caused by a mutation in the gene that codes for an enzyme called hexosaminidase-A (Hex-A). Hex A CDNA from normal and a Tay-Sachs individual was sequenced using the same primer. This is the coding strand and starts in-frame at amino acid position #78. Results are shown below. Read the darkest band in each row. Normal Tay-Sachs (-) ATG C ATG C (+) a. Write each coding strand DNA sequence, normal and Tay-Sachs 5' to 3' b. Write the amino acid sequence that will be translated from each sequence, normal and Tay-Sachs C. Describe the type of mutation? Predict the effect of this mutation on the Hex A protein.
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