19,21 Disease Controlgroup groupAllele A 25,35024,133Allele CAllele C 24,650 25,867 Allele TSNP1SNP 2; risk allele is CSNP 3; risk allele is GSNP 2; risk allele is TSNP 3; risk allele is AResults are shown above for 3 biallelic SNPs on the same chromosome used in aGWAS examining SNP-trait correlations for a complex human disease trait. Tableentries show the number of people with the indicated SNP allele that have thedisease (disease group) or don't have the disease (control group). Which SNPwould have the highest -log₁0(p-value) score in a Manhattan plot summarizingresults of this GWAS, and which is the SNP "risk allele"?SNP 1; risk allele is ASNP2SNP 1; risk allele is CDiseaseControlgroupgroup1,4201,50948,580 48,491SNP3Allele GAllele ADisease Controlgroup group47,3603,1092,64046,891 A population has an inbreeding co-efficient of 0.9. Which of the followingstatements is consistent with this information?Oindividuals in this population are homozygous for alleles of most genesallelic variation for genes in this population is highindividuals in this population are heterozygous for alleles of most genesrandom mating in the population is commonthe population is in Hardy-Weinberg equilibrium

In a GWAS (Genome-Wide Association Study), the -log10(p-value) score for each SNP (Single Nucleotide…

Results are shown above for 3 biallelic SNPs on the same chromosome used in a GWAS examining SNP-trait correlations for a complex human disease trait. Tabl entries show the number of people with the indicated SNP allele that have the disease (disease group) or don't have the disease (control group). Which SNP would have the highest -log₁0(p-value) score in a Manhattan plot summarizing results of this GWAS, and which is the SNP "risk allele"?

Results are shown above for 3 biallelic SNPs on the same chromosome used in a GWAS examining SNP-trait correlations for a complex human disease trait. Tabl entries show the number of people with the indicated SNP allele that have the disease (disease group) or don't have the disease (control group). Which SNP would have the highest -log₁0(p-value) score in a Manhattan plot summarizing results of this GWAS, and which is the SNP "risk allele"?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter19: Population Genetics And Human Evolution

Section: Chapter Questions

Problem 10QP

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