Regulation of metabolic pathways most typically occurs at enzyme steps that are thermodynamically downhill and internal to the pathway. thermodynamically uphill and at the beginning or end of the pathway. thermodynamically downhill and at the beginning or end of the pathway. thermodynamically uphill and internal to the pathway.
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- Several general characteristics of metabolic reactions or reaction pathways are listed. Classify them into the appropriate metabolic category. utilize ATP Anabolism convert NAD+ to NADH convert small compounds to larger compounds Answer Bank convert NADPH to NADP+ generally exergonic (spontaneous) Catabolism convert large compounds to smaller compoundsDiscuss the role of enzymes in metabolic regulation by describing the following five mechanisms.11.1Cascade systems11.2 Futile cycle11.3Cellular compartmentalization 11.4 Covalent modification11.5 ZymogensWhich of the following is NOT true about metabolic pathways in general? They can be anabolic or catabolic They can be both energy-releasing (exergonic) and energy-requiring (endergonic) They are often made up of a series of chemical reactions They often have multiple different enzymes working in the same pathway Each metabolic pathway is entirely separate and does not interact or connect at all with other metabolic pathways
- In hepatocytes, the enzyme glucokinase catalyzes the ATP-coupled phosphorylation of glucose. Glucokinase binds both ATP and glucose, forming a glucose-ATP-enzyme complex. The enzyme then transfers the phosphoryl group directly from ATP to glucose. Select the advantages of phosphoryl group transfer compared to hydrolysis and subsequent phosphorylation? ATP hydrolysis is thermodynamically unfavorable compared to group transfer. Glucokinase increases the transition state energy, favoring glucose phosphorylation. The process takes advantage of the high phosphoryl group transfer potential of ATP. Reaction intermediates do not need to be present in excess. IncorrectWhy must metabolic pathways be regulated? Cite three ways by which metabolic pathways are regulated.Classify the following into either activation processes or inhibitions processes. Process Phosphorylation of a transport protein (i.e. pump) The binding of a substrate molecule at the active site of an enzyme The binding of a molecule at the active site of an enzyme, but in place of the substrate The allosteric binding of ATP to the phosphofructokinase (an enzyme part of glycolysis)
- For each of the statements below about the dUTPase enzyme, mark whether it is true or false. If it is false, change the language to make the statement true. _______If the dUTPase enzyme is the rate determining step in a larger metabolic pathway, the reaction likely lies near to equilibrium and is irreversible. _______For the dUTPase reaction, it is not likely that DG’ = DG°’ _______ dUTPase has a higher affinity for its substrate than for its product, but both of these are higher than the affinity for the transition state _______Kinetic analysis of dUTPase using Michaelis-Menten methods assumes that the formation of the E*S complex has a large negative value for DGThe capacity to do work best defines: a metabolic pathway. entropy. kinetic or potential energy. a chemical equilibrium. thermodynamics.Which of the following statements regarding enzyme catalysis is false? All options are false. Once formed, the transition state slowly proceeds to forming the product at a rate determined by cofactor binding The free energy of binding of the enzyme to the transition state is more favorable than the free energy of binding of the enzyme to the substrate The substrate and active site of the enzyme are solvated to promote enzyme-substrate interaction Once formed, the product dissociates from the enzyme after ATP hydrolysis in order to regenerate the active site
- Complete the interrelated pathways by providing the neccesary metabolite, enzyme, reaction or metabolic pathway. Use abbreviations/acronyms (except for coenzyme)For Glycolysis what are steps of cellular respiration for both aerobic (oxygen present) and anaerobic (without oxygen) respiration. what are the Inputs and Outputs: Clearly indicate the key substrates, intermediates, and products at each stage. Location: Show where this stage of cellular respiration occurs within the cell (e.g., cytoplasm, mitochondria). Energy Production: Highlight the ATP and NADH production at this stage. Oxygen: Show where oxygen is used in the process (e.g., ETC) and where carbon dioxide is produced. Electron Carriers: Indicate the role of electron carriers such as NAD+ and FAD in transferring eleDiagrams: Use diagrams or icons to represent the structures and molecules involved, such as the mitochondria, glucose, ATP, and oxygen. Key Information like important facts or formulas relevant to cellular respiration, like the chemical equations for each stage.Describe the role that compartmentation plays in the regulation of metabolic pathways. Provide several examples.