QUESTION 1 Which of the following may occur as a result of cross-talk? (Select ALL correct answers) A cell may have a stronger response to a ligand than usual A cell may have a weaker response to a ligand than usual OA signaling pathway may branch, leading to two responses O The ligand may be blocked from activating the receptor

A hormone epinephrine binds to G-protein coupled receptor and activate multiple signaling pathways to induce "fight- or-flight" response. In these signaling pathways, which enzyme is responsible for the generation of IP3, a second messenger for calcium release from endoplasmic reticulum? O adenylyl cyclase O protein kinase C O protein kinase A O phospholipase C O calmodulin

Please answer both, thank you

From the Hill Plot below, the of the first binding event for the receptor-ligand system under study is: Q1 4nM Ο 10 μΜ -2 nM 2 nM Calculate the Hill Coefficient from the receptor-ligand binding data below: Q2 4 100 2 3 (0-1) 60 log 10 8 6 4 2 0 -2 -4 -6 -6 -4 -2 0 2 4 log [L] (nM) 6 8 10

In which of the following pathways are the receptor and ligand, both, membrane bound proteins? O Hedgehog signaling pathway Wnt signaling pathway Notch/Delta signaling pathway Cytokine receptors - JAK/STAT signaling pathway

A signaling molecule M is active when it is phosphorylated (M-P). The M-P has downstream target molecules in nucleus. Provide a possible mechanism by which M does its job

2 of 16 Compound Binds to Elicits biological receptor response A Yes Yes B Yes No C No No Refer to the table above. Compound X is the natural ligand that binds to a receptor and stimulates a signal transduction pathway associated with the receptor. Based on the information given in the table, what are the roles of compounds A, B, and C? O A is an antagonist, B is an agonist, and C is a ligand. A is an agonist, B is an antagonist, and C has no role. A is a ligand, B has no role, and C is an antagonist. A is an agonist, B is an antagonist, and C is an agonist. A has no role, B is an agonist, and C is an antagonist.

When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events in the correct order from 1st to the last step.

Answer question 38

5 of 16 What is the timecourse for the cell signalling mechanism evoked by ligand gated ion channel receptors? O Days. Hours. Milliseconds. Seconds. Microseconds.