Promoter 5' UTR Coding region Transcription start site 5'-TACCCAGATAATATATACGCATGACACATATGGACACCGATTATAAAGATATCTACTGCCGCGAGAATTATAG-3' 3' UTR Translation start codon Translation stop codon For each DNA sequence below, there is a single nucleotide mutation in the DNA sequence. For all examples, the mutation is highlighted in orange. A codon table is provided on the second page for your reference. Answer each of the following questions for EACH DNA sequence: A) what type of mutation is shown based on the nature of the genetic change (frameshift mutation or point mutation; if a point mutation, transition or transversion) B) what type of mutation is shown based on the functional impact on the organism (frameshift, silent, missense, nonsense, noncoding) C) What do you predict the effect of that mutation will be on either the structure or function of a protein, or on the phenotype of the organism. Explain your answer. For this part, there are some examples where you should know exactly the effect of the mutation, and some where you may have to infer this information based on the location of the mutation.
Promoter 5' UTR Coding region Transcription start site 5'-TACCCAGATAATATATACGCATGACACATATGGACACCGATTATAAAGATATCTACTGCCGCGAGAATTATAG-3' 3' UTR Translation start codon Translation stop codon For each DNA sequence below, there is a single nucleotide mutation in the DNA sequence. For all examples, the mutation is highlighted in orange. A codon table is provided on the second page for your reference. Answer each of the following questions for EACH DNA sequence: A) what type of mutation is shown based on the nature of the genetic change (frameshift mutation or point mutation; if a point mutation, transition or transversion) B) what type of mutation is shown based on the functional impact on the organism (frameshift, silent, missense, nonsense, noncoding) C) What do you predict the effect of that mutation will be on either the structure or function of a protein, or on the phenotype of the organism. Explain your answer. For this part, there are some examples where you should know exactly the effect of the mutation, and some where you may have to infer this information based on the location of the mutation.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Please answer A, B, and C for codon sequence 1 only
Transcribed Image Text:Use the sequence of DNA below as your reference point; this single-stranded DNA sequence is
the coding strand of a gene, which means the mRNA sequence is identical (not complementary)
to this sequence except that T's are replaced with U's. You do not have to convert any part of
the DNA sequence into a complementary strand for this part of the assignment - you
should just use the DNA sequence as given.
Note: for simplicity, not every sequence needed for gene expression is included in this gene -
for example, you won't necessarily find a Shine Dalgarno sequence in the mRNA 5' UTR. Use
only the information labeled on the DNA sequence to answer each question.
Promoter
5' UTR
Coding region
Transcription start site
5'-TACCCAGATAATATATACGCATGACACATATGGACACCGATTATAAAGATATCTĄCTGCCGCGAGAATTATAG-3′
3' UTR
Translation start codon
Translation stop codon
For each DNA sequence below, there is a single nucleotide mutation in the DNA sequence. For
all examples, the mutation is highlighted in orange. A codon table is provided on the second
page for your reference. Answer each of the following questions for EACH DNA sequence:
A) what type of mutation is shown based on the nature of the genetic change
(frameshift mutation or point mutation; if a point mutation, transition or transversion)
B) what type of mutation is shown based on the functional impact on the organism
(frameshift, silent, missense, nonsense, noncoding)
C) What do you predict the effect of that mutation will be on either the structure or
function of a protein, or on the phenotype of the organism. Explain your answer.
For this part, there are some examples where you should know exactly the effect of
the mutation, and some where you may have to infer this information based on the
location of the mutation.
Transcribed Image Text:15'-TACCGAGATAATATATACGCATGACACATATGGACACCGATTATAAAGATATCTAGTGCCGCGAGAATTATAG-3'
2 5'-TACCCAGATAATATATACGCATGACACATATGGACACAGATTATAAAGATATCTAGTGCCGCGAGAATTATAG-3′
3 5'-TACCCAGATAATATATACGCATGACACATATGGACACCGATAATAAAGATATCTAGTGCCGCGAGAATTATAG-3'
4 5'-TACCCAGATAATATATACGCATGACACATATGGACACCGATTAGAAAGATATCTAGTGCCGCGAGAATTATAG-3'
5 5'-TACCCAGATAATATATACGCATGACACATATGGACACCGATTATCAAAGATATCTAGTGCCGCGAGAATTATAG-3′
65'-TACCCAGATAATATATACGCATGACACATATGGACACCGATTATAAAGATATCTAGTGCCGCGAGGATTATAG-3′
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