Prepare 2,3-dimethylbutanoic acid via the Malonic Ester Synthesis route

Give the major organic product(s) of the following reactions for a)

Show the synthesis СООН COOH

2.1 Draw the mechanism for the base catalyzed tautomerization below: NaOH/H₂O HO 'N HN 2.2 There is a bond rotation about one N-C bond that leads to a conformational change between the two tautomers. What drives this conformational change when moving from the compound on the left to the compound on the right?

Provide the structure of the major organic product in the following reaction.

Give the structure of the organic product formed after the following series of reactions. Br Gee die struktuur van die organiese produk wat gevorm word na die volgende reeks van reaksies. 1) Mg 2) 4-methylpentanal | 4-metielpentanaal 3) PBr3 4) propylamine | propielamien 5) NaHCO3

Enamines can serve as enolate surrogates in reactions at the a-carbon. In the reaction sequence, the structures of the enamine addition product – the initial zwitterion and its neutral tautomer – are shown. Draw the structures of the two reactants forming these intermediates, and draw the structure of the final product, obtained via hydrolysis of the neutral intermediate. initial zwitterionic intermediate neutral intermediate tautomerization Reactants H,0 hydrolysis product Draw the two reactants. Draw the hydrolysis product. Select Draw Rings More Erase Select Draw Rings More Erase H H

Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. CI H₂N OH • You do not have to consider stereochemistry. • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g., Na+, I, in your answer. • In cases where there is more than one answer, just draw one. Sn [F