Parental strand -MutH -Newly made strand Mutl -Muts Incorrect MutH makes a cut in the nonmethylated strand. MutU (not shown) separates the DNA strands at the cleavage site, and an exonuclease (not shown) digests the nonmethylated strand until It passes the site where MutS is bound, removing the Incorrect base. base MutH cleavage site DNA polymerase fills in the vacant reglon. DNA ligase seals the end. The mismatch has been repalred correctly. А Н FIGURE 19.20 Mimatch repair in E. coli. In this example, the methylated adenine is designated with an m.
Parental strand -MutH -Newly made strand Mutl -Muts Incorrect MutH makes a cut in the nonmethylated strand. MutU (not shown) separates the DNA strands at the cleavage site, and an exonuclease (not shown) digests the nonmethylated strand until It passes the site where MutS is bound, removing the Incorrect base. base MutH cleavage site DNA polymerase fills in the vacant reglon. DNA ligase seals the end. The mismatch has been repalred correctly. А Н FIGURE 19.20 Mimatch repair in E. coli. In this example, the methylated adenine is designated with an m.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
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Which of the three Mut proteins is responsible for ensuring that the mismatched base in the newly made daughter strand is the one that is removed?
Transcribed Image Text:Parental
strand
-MutH
-Newly
made
strand
Mutl
-Muts
Incorrect
MutH makes a cut in the
nonmethylated strand. MutU
(not shown) separates the DNA
strands at the cleavage site, and
an exonuclease (not shown) digests
the nonmethylated strand until
It passes the site where MutS is
bound, removing the Incorrect base.
base
MutH cleavage site
DNA polymerase fills in
the vacant reglon. DNA
ligase seals the end.
The mismatch has been
repalred correctly.
А Н
FIGURE 19.20 Mimatch repair in E. coli. In this
example, the methylated adenine is designated with an m.
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