Paclitaxel (Taxol) is an anticancer drug which effects mitosis.  Specifically, it prevents disassembly of the mitotic spindle, which prevents spindle fibers from shortening.  Which phase of mitosis would this directly effect? Why would this stop cell division overall and lead to cell death?

The drug taxol is extracted from the bark of yew trees.  It binds tightly to microtubules and stabilizes them.  When added to cells, it causes much of the free tubulin to assemble into microtubules.  Taxol can be used as an anticancer drug.  At the molecular level, what does the drug prevent?  At the cellular level, what part of cell division does it prevent?  Be specific.

What is the genetic significance of mitosis (I.e., how do the daughter cells compare to the original parent cell on their genetic makeup)?

In the absence of cdc25 cells would not be able to undergo mitosis. True or False?