One of the steps in psilocybin biosynthesis is the phosphorylation of 4-hydroxytryptamine By the enzyme Psik as shown below, that involves the hydrolysis of ATP. NH₂ & 4-hydroxytryptamine ATP Psik ADP HO HO norbaeocystin The standard free energy changes for each reaction is shown in the Table below. AG 27.7 kJ/mol -32.2 kJ/mol (b) What is the equilibrium constant at 37 °C? reaction 4-hydroxytryptamine + P→ norbaeocystin ATP → ADP+ Pi (a) Write the net reaction. What is the standard free energy change for the net reaction? (c) In the cell, the concentration of ATP is 3.1 mM, the concentration of P; Is 5.90 mM, and the Concentration of ADP is 220 μM. What will AG Be if the concentration of norbaeocystin Is always kept at 1/100 of the concentration of 4-hydroxytryptamine?

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 13P
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One of the steps in psilocybin biosynthesis is the phosphorylation of 4-hydroxytryptamine
By the enzyme Psik as shown below, that involves the hydrolysis of ATP.
NH₂
OH
HO
Psik
HO
of A&
ADP
4-hydroxytryptamine
ATP
norbaeocystin
The standard free energy changes for each reaction is shown in the Table below.
J
reaction
4-hydroxytryptamine + P₁ → norbaeocystin
ATP → ADP+ Pi
(b) What is the equilibrium constant at 37 °C?
AG
27.7 kJ/mol
-32.2 kJ/mol
(a) Write the net reaction. What is the standard free energy change for the net reaction?
(c) In the cell, the concentration of ATP is 3.1 mM, the concentration of P; Is 5.90 mM, and the
Concentration of ADP is 220 μM. What will AG Be if the concentration of norbaeocystin
Is always kept at 1/100 of the concentration of 4-hydroxytryptamine?
Transcribed Image Text:One of the steps in psilocybin biosynthesis is the phosphorylation of 4-hydroxytryptamine By the enzyme Psik as shown below, that involves the hydrolysis of ATP. NH₂ OH HO Psik HO of A& ADP 4-hydroxytryptamine ATP norbaeocystin The standard free energy changes for each reaction is shown in the Table below. J reaction 4-hydroxytryptamine + P₁ → norbaeocystin ATP → ADP+ Pi (b) What is the equilibrium constant at 37 °C? AG 27.7 kJ/mol -32.2 kJ/mol (a) Write the net reaction. What is the standard free energy change for the net reaction? (c) In the cell, the concentration of ATP is 3.1 mM, the concentration of P; Is 5.90 mM, and the Concentration of ADP is 220 μM. What will AG Be if the concentration of norbaeocystin Is always kept at 1/100 of the concentration of 4-hydroxytryptamine?
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