Nursing 1.1 Is there a possibility that by manipulating the microenvironment, we could disrupt the signals controlling the phenotype of cancer (stem?) cells.?
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Panswer Nursing 1.1 Is there a possibility that by manipulating the microenvironment, we could disrupt the signals controlling the
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- 1. Brief introduction which introduces ALP as a diagnostic tool in cancer and create Graphical Abstract to summarise the role of ALP in cancer?CASE STUDY Cancer-killing bacteria Ralph, a 57-year-old man, was diagnosed with colon cancer.His oncologist discussed the use of radiation andchemotherapy as treatments, both of which can causedebilitating side effects. Ralph decided to explore other optionsand went to a cancer clinic. He learned that researchers in asynthetic biology program were testing the use of geneticallymodified bacterial cells designed to selectively invade specifictumors and kill cancer cells, with no effects on normal cells.Ralph decided to participate and was informed that he wouldbe part of a phase III trial, comparing the effects of the modifiedbacterial cell treatment against conventional chemotherapy.However, as part of the trial, he would be randomly assigned toreceive one or the other treatment. He was disappointed to learnthis, because he assumed that he would receive the bacterialtherapy.Question: Informed consent is legally and ethically required beforesomeone participates in a clinical trial.…Hi, can you elaborate about: 1. MyoD to be used to manipulate cancer cells at an early stage and then be used as a treatment. 2. Angiogenesis is a major function for tumor cells to grow, so if we break off the blood supply, would this result in better treatment?
- 34. List and describe common manifestations of cancer? a) Local effects of tumors b) Systemic effects of malignant tumors.Lung cancer mitotic index: 0.25 Breast cancer mitotic index: 0.35 Skin cancer mitotic index: 0.4 Looking at the mitotic index for all 3 cancer types, which one is likely to be the most resistant (least affected) to the growth-inhibiting effects of traditional chemotherapy drugs that target rapidly dividing cells?How to detect cancer? What are a few approaches to treat cancer?
- Figure 17.15 In 2011, the United States Preventative Services Task Force recommended against using the PSA test to screen healthy men for prostate cancer. Their recommendation is based on evidence that screening does not reduce the risk of death from prostate cancer. Prostate cancer often develops very slowly and does not cause problems, while the cancer treatment can have severe side effects. The PCA3 test is considered to be more accurate, but screening may still result in men who would not have been harmed by the cancer itself suffering side effects from treatment. What do you think? Should all healthy men be screened for prostate cancer using the PCA3 or PSA test? Should people in general be screened to find out if they have a genetic risk for cancer or other diseases?Tissues and differentiation a)Explain what is meant by termination and differentiation ).b) Explain the difference between an oncogenic and a tumour suppressor gene and describe how they are involved in the onset of cancerSkin cancer carries a lifetime risk nearly equal to that of allother cancers combined. Following is a graph [modified fromK. H. Kraemer (1997). Proc. Natl. Acad. Sci. (USA) 94:11–14]depicting the age of onset of skin cancers in patients with orwithout XP, where the cumulative percentage of skin cancer is plotted against age. The non-XP curve is based on 29,757 cancerssurveyed by the National Cancer Institute, and the curverepresenting those with XP is based on 63 skin cancers from theXeroderma Pigmentosum Registry.
- 1) Briefly outline the location, isolation , characterisation, benefits, and limitations of adult stem cells in TERM 2) Describe and compare the various potencies exhibited by stem cell pheno type 3) Outline the in vitro/in vivo mechanical forces that can be used to influence the quality of cell response and tissue formation obtained by TE..Q2) А. As long as the optimum dosage of the ionizing radiation is achieved it can be used for treatment of cancer. Can you explain the working principle of the treatment? - Hint: Consider the effect of treatment on both healthy and cancer cells В. Please explain how DNA viruses and telomere shortening may cause the onset of cancer.Hi, can you elaborate about the relationships between Non-small-cell lung carcinoma and mutations in p53 and RAS protein?
