Next, it's important to understand how the gene would be transcribed and translated. 1 agagtctcct cagacgccga gatgctggtc atggcgcccc gaaccgtcct cctgctgctc 61 tcggcggccc tggccctgac cgagacctgg gccggtgagt gcgggtcggg agggaaatgg 121 cctctgccgg gaggagcgag gggaccgсag gcgggggcgc atgacctcag gagccgcgcc 181 gggaggaggg tcgggcgggt ctcagcccct cctcaccccc aggctcccac tccatgtggt 241 atttctacac ctccgtatcc cggcccagcc gcggggagcc ccgcttcatc tcagtgggct 301 acqtggacga cacccagttc gtgaggttcg acagcgacgc cgcgagtccg agagaggagc 361 cgcgggcgcc gtggatagag caggaggggc cggagtattg ggaccggaac acacagatct 421 acaaggccca ggcacagact gaccgagaga gcctgcggaa cctgcgcttc tactacaacc 481 agagcgaggc cgttgcgtga ccccggcccg gggcgcaggt cacgactccc catcccccac 541 gtacggcccg ggtcgccccg agtctccggg tccgagatcc gcctccctga ggccgcggga a) coding region i) What is the length of the coding region (in nucleotides)? ii) Explain how you arrived at your answer for (i). iii) Which nucleotides are included in the coding region (e.g. nucleotides #20-50, inclusive)? b) polypeptide i) What will be the length of the resulting polypeptide (in amino acids)? Note that in some proteins the first methionine (encoded by the ATG start codon) is cleaved off, however the methionine is retained in this particular protein. ii) Explain how you calculated the number you provided for (i), above. c) C-terminal domain i) You're interested in expressing the C-terminal domain of the protein, which is encoded by amino acids number 45-56 (the C-terminal portion (domain) of a protein includes amino acids encoded by the nucleotides at the 3' end of the coding sequence). What is the range of nucleotides that corresponds to this region (e.g. nucleotides #20-50, inclusive)? Note that sometimes you may want to include the stop codon but in this case you do not.
Next, it's important to understand how the gene would be transcribed and translated. 1 agagtctcct cagacgccga gatgctggtc atggcgcccc gaaccgtcct cctgctgctc 61 tcggcggccc tggccctgac cgagacctgg gccggtgagt gcgggtcggg agggaaatgg 121 cctctgccgg gaggagcgag gggaccgсag gcgggggcgc atgacctcag gagccgcgcc 181 gggaggaggg tcgggcgggt ctcagcccct cctcaccccc aggctcccac tccatgtggt 241 atttctacac ctccgtatcc cggcccagcc gcggggagcc ccgcttcatc tcagtgggct 301 acqtggacga cacccagttc gtgaggttcg acagcgacgc cgcgagtccg agagaggagc 361 cgcgggcgcc gtggatagag caggaggggc cggagtattg ggaccggaac acacagatct 421 acaaggccca ggcacagact gaccgagaga gcctgcggaa cctgcgcttc tactacaacc 481 agagcgaggc cgttgcgtga ccccggcccg gggcgcaggt cacgactccc catcccccac 541 gtacggcccg ggtcgccccg agtctccggg tccgagatcc gcctccctga ggccgcggga a) coding region i) What is the length of the coding region (in nucleotides)? ii) Explain how you arrived at your answer for (i). iii) Which nucleotides are included in the coding region (e.g. nucleotides #20-50, inclusive)? b) polypeptide i) What will be the length of the resulting polypeptide (in amino acids)? Note that in some proteins the first methionine (encoded by the ATG start codon) is cleaved off, however the methionine is retained in this particular protein. ii) Explain how you calculated the number you provided for (i), above. c) C-terminal domain i) You're interested in expressing the C-terminal domain of the protein, which is encoded by amino acids number 45-56 (the C-terminal portion (domain) of a protein includes amino acids encoded by the nucleotides at the 3' end of the coding sequence). What is the range of nucleotides that corresponds to this region (e.g. nucleotides #20-50, inclusive)? Note that sometimes you may want to include the stop codon but in this case you do not.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
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