Next, it's important to understand how the gene would be transcribed and translated. 1 agagtctcct cagacgccga gatgctggtc atggcgcccc gaaccgtcct cctgctgctc 61 tcggcggccc tggccctgac cgagacctgg gccggtgagt gcgggtcggg agggaaatgg 121 cctctgccgg gaggagcgag gggaccgсag gcgggggcgc atgacctcag gagccgcgcc 181 gggaggaggg tcgggcgggt ctcagcccct cctcaccccc aggctcccac tccatgtggt 241 atttctacac ctccgtatcc cggcccagcc gcggggagcc ccgcttcatc tcagtgggct 301 acqtggacga cacccagttc gtgaggttcg acagcgacgc cgcgagtccg agagaggagc 361 cgcgggcgcc gtggatagag caggaggggc cggagtattg ggaccggaac acacagatct 421 acaaggccca ggcacagact gaccgagaga gcctgcggaa cctgcgcttc tactacaacc 481 agagcgaggc cgttgcgtga ccccggcccg gggcgcaggt cacgactccc catcccccac 541 gtacggcccg ggtcgccccg agtctccggg tccgagatcc gcctccctga ggccgcggga a) coding region i) What is the length of the coding region (in nucleotides)? ii) Explain how you arrived at your answer for (i). iii) Which nucleotides are included in the coding region (e.g. nucleotides #20-50, inclusive)? b) polypeptide i) What will be the length of the resulting polypeptide (in amino acids)? Note that in some proteins the first methionine (encoded by the ATG start codon) is cleaved off, however the methionine is retained in this particular protein. ii) Explain how you calculated the number you provided for (i), above. c) C-terminal domain i) You're interested in expressing the C-terminal domain of the protein, which is encoded by amino acids number 45-56 (the C-terminal portion (domain) of a protein includes amino acids encoded by the nucleotides at the 3' end of the coding sequence). What is the range of nucleotides that corresponds to this region (e.g. nucleotides #20-50, inclusive)? Note that sometimes you may want to include the stop codon but in this case you do not.

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Task #2: Examine the gene, transcript and polypeptide sequences
Next, it's important to understand how the gene would be transcribed and translated.
A
1 agagtctcct cagacgccga gatgctggtc atggcgcccc gaaccgtcct cctgctgctc
61 tcggcggccc tggccctgac cgagacctgg gccggtgagt gcgggtcggg agggaaatgg
121 cctctgccgg gaggagcgag gggaccgcag gcgggggcgc atgacctcag gagccgcgcc
181 gggaggaggg tcgggcgggt ctcagcccct cctcaccccc aggctcccac tccatgtggt
241 atttctacac ctccgtgtcc cggcccqgcc gcggggagcc ccgcttcatc tcagtgggct
301 acgtggacga cacccagttc gtgaggttcg acagcgacgc cgcgagtccg agagaggagc
361 cgcgggcgcc gtggatagag caggaggggc cggagtattg ggaccggaac acacagatct
421 acaaggccca ggcacagact gaccgagaga gcctgcggaa cctgcgcttc tactacaacc
481 agagcgaggc cgttgcgtga ccccggcccg gggcgcaggt cacgactccc catcccccac
541 gtacggcccg ggtcgccccg agtctccggg tccgagatcc gcctccctga ggccgcggga
a) coding region
i) What is the length of the coding region (in nucleotides)?
ii) Explain how you arrived at your answer for (i).
iii) Which nucleotides are included in the coding region (e.g. nucleotides #20-50, inclusive)?
b) polypeptide
i) What will be the length of the resulting polypeptide (in amino acids)? Note that in some
proteins the first methionine (encoded by the ATG start codon) is cleaved off, however the
methionine is retained in this particular protein.
ii) Explain how you calculated the number you provided for (i), above.
c) C-terminal domain
i) You're interested in expressing the C-terminal domain of the protein, which is encoded by
amino acids number 45-56 (the C-terminal portion (domain) of a protein includes amino
acids encoded by the nucleotides at the 3' end of the coding sequence). What is the range of
nucleotides that corresponds to this region (e.g. nucleotides #20-50, inclusive)? Note that
sometimes you may want to include the stop codon but in this case you do not.
ii) Underline this region in the gene sequence (above).
Transcribed Image Text:Task #2: Examine the gene, transcript and polypeptide sequences Next, it's important to understand how the gene would be transcribed and translated. A 1 agagtctcct cagacgccga gatgctggtc atggcgcccc gaaccgtcct cctgctgctc 61 tcggcggccc tggccctgac cgagacctgg gccggtgagt gcgggtcggg agggaaatgg 121 cctctgccgg gaggagcgag gggaccgcag gcgggggcgc atgacctcag gagccgcgcc 181 gggaggaggg tcgggcgggt ctcagcccct cctcaccccc aggctcccac tccatgtggt 241 atttctacac ctccgtgtcc cggcccqgcc gcggggagcc ccgcttcatc tcagtgggct 301 acgtggacga cacccagttc gtgaggttcg acagcgacgc cgcgagtccg agagaggagc 361 cgcgggcgcc gtggatagag caggaggggc cggagtattg ggaccggaac acacagatct 421 acaaggccca ggcacagact gaccgagaga gcctgcggaa cctgcgcttc tactacaacc 481 agagcgaggc cgttgcgtga ccccggcccg gggcgcaggt cacgactccc catcccccac 541 gtacggcccg ggtcgccccg agtctccggg tccgagatcc gcctccctga ggccgcggga a) coding region i) What is the length of the coding region (in nucleotides)? ii) Explain how you arrived at your answer for (i). iii) Which nucleotides are included in the coding region (e.g. nucleotides #20-50, inclusive)? b) polypeptide i) What will be the length of the resulting polypeptide (in amino acids)? Note that in some proteins the first methionine (encoded by the ATG start codon) is cleaved off, however the methionine is retained in this particular protein. ii) Explain how you calculated the number you provided for (i), above. c) C-terminal domain i) You're interested in expressing the C-terminal domain of the protein, which is encoded by amino acids number 45-56 (the C-terminal portion (domain) of a protein includes amino acids encoded by the nucleotides at the 3' end of the coding sequence). What is the range of nucleotides that corresponds to this region (e.g. nucleotides #20-50, inclusive)? Note that sometimes you may want to include the stop codon but in this case you do not. ii) Underline this region in the gene sequence (above).
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