Mutations in proto-oncogenes that turn them into oncogenes tend to be dominant, while cancer-causing mutations in tumor suppressor genes tend to be recessive. Please explain why.

Q: Define tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to…

A: The repeated and uncontrollable division of cells forms a large mass called the tumor. Tumors might…

Q: What is meant by the "two-hit" model of cancer development? Describe this theory in detail and…

A: Two-hit hypothesis : The "two-hit" hypothesis or model was first proposed by geneticist Alfred…

Q: The rb gene encodes a protein that inhibits E2F, a transcriptionfactor that activates several genes…

A: Abnormal and unnecessary growth of cells termed cancer. Mutations in DNA causes cancer. In the…

Q: With regard to cancer cells, which of the following are true? DA Cancer cells are clonal, meaning…

A: Ans: Cancer: It is the uncontrolled growth of cells in response to or due to mutation.

Q: Explain how mutations in tumor-suppressor genes can be recessive at the level of the cell but cause…

A: A tumor suppressor gene is normally a cellular gene that regulates the cell proliferation or DNA…

Q: why EGFR play a role in CRC and other cancer?

A: EGFR : It is epidermis growth factor receptor.  CRC:  Colorectal cancer. EGFR : It is one of the…

Q: Compare and contrast oncogenes and tumor suppressors. Contrast oncogenes and proto-oncogenes.…

A: Genetic changes are the primary cause of cancer, an incredibly complicated and multidimensional…

Q: For a gene to be cancer-inducing, both copies of the gene must be affected, explain it with example.

A: Cancer inducing gene The gene having the potential to cause cancer are called as cancer inducing…

Q: Mrs. Ortez has type III breast cancer and is now concluding the trial portion of a certain research…

A: Stage III breast cancer is a stage where the cancer has spread beyonf the tumor region and might…

Q: Explain how mutations in oncogenes and in tumor suppressorgenes cause cancer.

A: Cancer is a group of diseases that involves abnormal growth of the cell. These cells have the…

Q: BRCA1 and BRCA2 are genes that encode proteins involved in DNA repair. If DNA can not be repaired,…

A: BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that make proteins that aid…

Q: Define tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene…

A: Tumor-supressor genes: Tumor-suppressor genes is defined as normal genes that will slow down the…

Q: Although tobacco smoking is responsible for a large number of human cancers, not all smokers develop…

A: Cancer refers to the uncontrolled cell division caused by the mutations in the genes which control…

Q: What is the difference between an oncogene and a tumor-suppressorgene? Give two examples of each…

A: Cancer is defined as the biological disorder in which the cells undergo uncontrolled growth and cell…

Q: Discuss how oncogenes and tumor suppressor genes are related to genes involved in the control of…

A: Tumor suppressor genes are the regular genes present in the genome which are important for the…

Q: Compare and contrast oncogenes and tumor suppressor genes.

A: Oncogenes are those genes that have the potential to cause cancer. These genes are often mutated or…

Q: Which combination of oncogenes and tumor suppressors is MOST likely to develop a tumor? 1) decreased…

A: Tumor is the characteristic feature of the abnormal cell division. The cell division rate is faster…

Q: Explain about the Cancer-causing gene formed by a mutation in a proto-oncogene ?

A: In genetics, the mutation is defined as the changes or alteration in the DNA sequences which result…

Q: For the normal cell to become a cancer cell, mutations should take place in protooncogenes to become…

A: Cancer cells divide incessantly, producing solid tumors or infiltrating the bloodstream with…

Q: Protein P, normally stimulates apoptosis or cell death when activated. Consider a cell with a…

A: The construction of this question gives us an  information about the nature of protein P, P when…

Q: Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor…

A: Translesion synthesis (TLS) is a method of overcoming stopped replication in which particular…

Q: Suppose Nicole recently learned that she inherited a mutant BRCA1 allele from her mother, who had…

A: BRCA1 is a tumor suppressor gene usually expressed in breast cells. It is responsible for repairing…

Q: a often survive until adulthood and produce children, what is their risk of developing other types…

A: Retinoblastoma is  an uncommon type of eye cancer that occurs in the young children and in this type…

Q: According to the multi-hit model, more than one mutation must occur in a cell for cancer to develop.…

A: A new multihit model of carcinogenesis is produced for use in assessing age-explicit disease rate…

Q: Describe how mutations in genome maintenance factors promote tumorigenesis. Why would inactivation…

A: The cells are basic units of life. When any mutation in the gene takes place due to any radiation or…

Q: In some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an…

A: Cancer is an uncontrolled division of cell that has a defunct apoptosis mechanism. Usually, when…

Q: The palladin gene, which plays a role in pancreatic cancer (see theintroduction to this chapter), is…

A: A disease is an abnormal condition that negatively impacts the structure and function of an…

Q: In 2010, the U.S. Department of Health and Human Services added alcoholic beverages to its list of…

A: Cancer refers to  large number of diseases that are characterized by the development of abnormal…

Q: Which of the following statements about cancer is false? (a) oncogenes arise from mutations in…

A: Proto Oncogenes are the genes that cause cancer when there are alterations in them. Several factors…

Q: Do you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras…

A:

Q: Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, Bcl-2,…

A: Proto-oncogene is a normal gene which have many different functions in the cell, like providing…

Q: Explain the normal regulation of proto-oncogenes and tumor suppressor genes that prevents cells from…

A: Oncogenes and tumour suppressor genes are two types of genes that relate cell cycle regulation to…

Q: "once cells have differentiated to their final specialized forms, they never again alter expression…

A: As an individual develops, cell differentiation progresses from the zygote's basic structure to a…

Q: "In most differentiated tissues, daughter cells retain a memory of gene expression patterns that…

A: The expression of specific genes inside each cell type is what causes cells to differentiate into…

Q: Mutations in p53 are commonly associated with malignant tumor formation. Do deleterious mutations in…

A: Mutations are the phenomenon in which certain nitrogenous bases are removed or added spontaneously…

Q: There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes,…

A: It is an uncontrollable cell division that get metastasized into surrounding tissues.