Match the antibody isotype with its functional characteristics. Highly effective at activating complement, too large to get to infected tissues Crosses cells, including the placenta, neutralizes toxins Dimeric form crosses the intestinal epithelia using PlgR Crosslinking on the surface of the mast cell leads to degranulation and release of histamine Although the exact function of this isotype is unknown, we know it does NOT fix complement ✓Choose... IgD IgM IgG IgA IgE Choose...

pathogenic bacteria in gut lumen binds binds capture and transfer to A B submucosa inhibits binds produces produces epithelial cells of small intestine klocated below B-cll follicle in Peyer's patches reside on reside presents among antigens E F capture and transfer from lumen presents engulf antigens pathogenic bacteria in gut submucosa D -lyse-

DRAW IT Sketch a B cell antigen receptor. Label the Vand C regions of the light and heavy chains. Label theantigen-binding sites, disulfide bridges, and transmembrane region. Where are these features located relativeto the V and C regions?

Why is the response to T-independent antigens important medically?

eds Antibodies (Immunoglobulins) Objective 14 Antibodies (immunoglobulins) are glycoproteins secreted by plasma cells. They are located in interstitial fluid, plasma (gamma globulin fraction) and in body secretions. onse A. Antibody Structure Heavy chain Antigen-binding site Light chain Insmakamos Hinge region Complement- binding site Stem region Macrophage binding site OHO (a) Antibody molecule OHO X = Disulfide bond Carbohydrate four polypeptide chains (two heavy, two light) chains are held together by covalent disulfide bonds (S=S) each heavy chain and each light chain has two functional areas: consists of highly variable amino acid sequences which forms the basis of antibody specificity; antigen binds here ????? to more conserved amino acid sequences; there are five basic sequences of amino acids, which define the 5 antibody classes (IgG, IgA, IgM, IgE and IgD); ????? each class has its own characteristic set of effector functions (see next page) Your notes: 4 40 4. 39

Shortly discuss the above antibodie structure? Please discuss at your own words . Discussion should be to the point (specific 5-6 lines).

TABLE 6 | Correlation between immune markers and age. Marker NCI PAN LCI LP NK activity (lysis %) R Spearman -0.406 -0.305 -0.239 -0.204 -0.016 Р 0.004 0.035 0.101 0.165 0.913 NCI, Neutrophil Chemotaxis Index; PAN, phagocytic activity of neutrophils; LCI, Lymphocyte Chemotaxis Index; LP, lymphocyte proliferation; NK, natural killer. p is the associated value to the corresponding statistical test.

this is for hypersensitivities topic Please select one example of surface molecules that inhibit complement protein activation and describe the mechanism of action ( please include one image and reference page)

please help me

It takes fewer molecules of IgM than IgG to cause precipitation. Why wouldthis be so?