LO 71- Explain why studying the epigenome is harder than studying the genome of an organism. Select all of the factors that make studying the epigenome more difficult than studying the genome: S 15 epigenetic changes are unstable and not heritable epigenome is bigger than the genome the epigenome cannot be 'sequenced' as the genome can the epigenome is variable across different types of cells epigenetic changes produce unobservable nucleotide sequence changes

LO 71- Explain why studying the epigenome is harder than studying the genome of an organism. Select all of the factors that make studying the epigenome more difficult than studying the genome: S 15 epigenetic changes are unstable and not heritable epigenome is bigger than the genome the epigenome cannot be 'sequenced' as the genome can the epigenome is variable across different types of cells epigenetic changes produce unobservable nucleotide sequence changes

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter16: Gene Expression

Section: Chapter Questions

Problem 10RQ: What are epigenetic modifications? the addition of reversible changes to histone proteins and DNA...

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a. What is your epigenome (i.e. epigenetics)? b. Does lifestyle affect your epigenome? Explain -c. Does your epigenome change with age? Explain d. What is epigenetic therapy? Is it working? Explain Edit View Insert Format Tools Table 12pt v Paragraph v в I Address DELL F7 F8 F9 F10 F1 F4 F5 F6 # % & 3 4 6. 7 8 9 Y ...
a. What is your epigenome (i.e. epigenetics)? b. Does lifestyle affect your epigenome? Explain c. Does your epigenome change with age? Explain d. What is epigenetic therapy? Is it working? Explain Edit View Insert Format Tools Table 12pt v Paragraph v BIUA 2v T? Addre DELL
LO 68 Identify the elements that make an epigenetic trait. Which of the following elements is necessary for an epigenetic effect to take place? Inheritance of the modification to offspring A modification in gene expression A modification of the nucleotide sequence A modification of the RNA sequence Environmental influence A mutation Inheritance of the modification
Define Epigenetic Inheritance Epigenetic inheritance Multiple Choice includes a subset of epigenetlc changes that are passed from parent to offspring across generations. occurs only in female offspring via processes like DNA methy ation is the inheritance of the poténtiol to have DNA changes occur, not the inheritance of actual epigenetic changes is always the result of environmental effects on the cells in an organism involves the inheritance of changes In gene expression thot offects oll traits in an organism Prey 1 of 14 Ne
A patient comes into your clinic exhibiting generic cancer symptoms. In order to help form a diagnosis, you ask about patient history and they tell you that they worked for years in an agricultural job, primarily in handling food for large bovine animals and then later working with insect pesticide treatment of grain fields. You decide to test for elevated levels of the environmental agent(s) in their body and focus your cancer diagnosis on based on the established associations of epigentic effects and cancer. O nickel and cadmium; stomach and skin cancer O benzene; breast, prostate and thyroid cancer O polycyclic aromatic hydrocarbons and benzene; lung, breast, stomach and skin cancer O arsenic and endocrine disruptors; skin, bladder, liver and kidney cancer
. Mutations in an autosomal gene in humans cause aform of hemophilia called von Willebrand disease(vWD). This gene specifies a blood plasma proteincleverly called von Willebrand factor (vWF). vWFstabilizes factor VIII, a blood plasma protein specified by the wild-type hemophilia A gene. Factor VIIIis needed to form blood clots. Thus, factor VIII is rapidly destroyed in the absence of vWF.Which of the following might successfully be employed in the treatment of bleeding episodes in hemophiliac patients? Would the treatments workimmediately or only after some delay needed forprotein synthesis? Would the treatments have only ashort-term or a prolonged effect? Assume that allmutations are null (that is, the mutations result in thecomplete absence of the protein encoded by the gene)and that the plasma is cell-free.a. transfusion of plasma from normal blood into avWD patientb. transfusion of plasma from a vWD patient into adifferent vWD patientc. transfusion of plasma from a hemophilia A…
LO74 Explain how epigenetic markers are inherited. How do epigenetic marks compare in monozygotic twins? They stay the same throughout their lives because monozygotic twins are genetically identical. They are similar early in life but are increasingly dissimilar with age. DNA methylation patterns are similar, but histone acetylation patterns are very different. They are different at birth, but a similar environment during childhood causes them to become more similar with time.
LO69 Identify whether a trait is epigenetic or genetic given an example. Determine if the following examples are epigenetic or genetic Methylation of C genes in rabbits during early development due to high temperatures causes a permanent change in fur coloration A change in BRCA gene sequence increases probability of breast cancer development after age 25 Smoking increases DNA methylation in the lungs. Methylation goes away slowly for people that quit smoking epigenetic both genetic
When chromatin is condensed, transcription cannot happen. Why not? RNA cannot access the promoter region of the gene DNA helicase cannot access the RNA strand RNA polymerase cannot access the DNA strand Transcription factors cannot access the termination region of the gene
G-LO37 Identify the consequences of mutations in different regions of a gene. The image below represents two strands of DNA: the top one corresponds to a healthy individual, and the bottom one of a sibling potentially affected with a disease due to genetic mutations Mutation 1 A + с AUA ACA AUG Met ACG GUU GUC GUA GUG Val GCU GCC GCA GCG It will result in mRNA produced Mutation 2 It will result in no mRNA produced 500 AGG The protein produced will be normal 500 + GGG Ala The Select all that applies about Mutation 1 (position -6): AAGLys AGA Arg GGU GGC GGA GGG GAC Asp GAA Glu GAGJ Gly The protein produced will have a different amino acid 1235 ATT 1235 TTT 070 2070 ALL The mutation occurs in the promoter region, and this means that the mRNA cannot be produced 1535 The mRNA and protein will both be normal because the mutation occurs outside of the consensus region of the promoter G 1535 с Affected
The following is true about epigenetic gene control: O epigenetic changes to the chromatin may result from childhood development epigenetic changes to the chromatin may result from chemicals in the environment O epigenetic changes to the chromatin may result in cancer O An example of a chromatin change is DNA methylation that prevents gene expression from that area of the DNA
. Null alleles (mutant genes) produce no protein product. This is a genetic change. However, epigeneticallysilenced genes also produce no protein product. Howdoes one determine experimentally whether a genehas been silenced by mutation or has been silencedepigenetically?