Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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- List and explain three reasons why
DNA replication is very accurate. Is this true for both prokaryotes and eukaryotes? Explain your reasoning.
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- What observations are consistent with the conclusion that DNA serves as the genetic material in eukaryotes? List and discuss them.arrow_forwardA major difference between prokaryotes and eukaryotes is the presence of a nucleus. What advantages and disadvantages may occur with having a cell’s genome packaged in a nucleus?arrow_forwardUsing the figure below, which end of the double helix,"A" or "B", would be considered the 5 prime end? B (type "A" or "B" in the blank) Which of the following statements would best explain your reasoning for question 1? 1 (type 1, 2 or 3 in the blank) The end of the DNA strand with the phosphate exposed is the 5 prime end The end of the DNA strand that shows the five carbon sugar pointing down is the 5 prime end The end of the DNA strand with the fifth carbon on the sugar molecule is the 5 prime endarrow_forward
- Medgie is creating his science fair project on DNA replication. His final display board shows the following. Human DNA Replication Steps Step 1 DNA unwinds in the nucleus Step 2 Complementary base pairs are deleted Step 3 DNA rewinds back together Step 4 The newly made DNA helix is placed in a cell formed in Mitosis According to Medgie's project, which of the following identifies and explains which of the steps is incorrect? O Step 4 is incorrect because not all human cells require DNA. O Step 3 is incorrect because the DNA remains unwound to be transcribed into RNA. Step 2 is incorrect because the complementary base pairs are used as a template, not deleted. Step 1 is incorrect because DNA doesn't unwind in the nucleus, instead it unwinds in the cytoplasm Previousarrow_forwardDNA polymerase occasionally incorporates the wrong nucleotide during DNA replication. If left unrepaired, the base-pair mismatch that results will lead to mutation in the next replication. As part of a template strand, the incorporated wrong base will direct the incorporation of a base complementary to itself, so the bases on both strands of the DNA at that position will now be different from what they were before the mismatch event. The MER-minus strain of yeast does not have a functional mismatch excision repair system, but it has normal base excision repair and nucleotide excision repair systems. Which of the following statements is correct about differences in the mutation spectrum between MER-minus and wildtype yeast? More than one answer is correct. Options: More point mutations will arise in MER-minus yeast. Fewer point mutations will arise in MER-minus yeast as compared with wildtype. Of the total point mutations that…arrow_forwardGive two example related with replication?arrow_forward
- What statement(s) apply to both eukaryotic and prokaryotic replication? Select all that apply. a. There is a single origin of replication. b. Replication is discontinuous on the lagging strand and continuous on the leading strand. c. The sliding clamp is composed of PCNA. d. Telomeres are replicated by telomerase. e. Helicase unwinds the helix. f. Replication is continuous on the lagging strand and discontinuous on the leading strand.arrow_forwardCompare and contrast prokaryotic and eukaryotic replication.arrow_forwardBriefly describe five ways by which DNA is packaged so that it can fit inside a eukaryotic nucleus.arrow_forward
- While the three previous paragraphs put on some details about enzymes, a Russian physician and chemist named Phoebus Levene focused on the three major components of a single nucleotide (phosphate, pentose sugar, and nitrogenous base) in 1919. He was also the first to discover the carbohydrate component of RNA (ribose), and carbohydrate component of DNA (deoxyribose). Years later, Levene finally identified how DNA and RNA molecules are put together Then in 1937, Hans Krebs discovered the most famous (probably) process that occur during cell respiration. This series of chemical reactions has three names such as the Citric Acid Cycle, Tricarboxylic Acid Cycle and Krebs Cycle. In this process, glucose and oxygen is converted to carbon dioxide, water, and energy. While working on bacterial samples, Oswald Avery first suggested in 1944 that the genetic material of the cell was possibly the deoxyribonucleic acid. In the middle of the 20th Century, Erwin Chargaff began to oppose Levene's…arrow_forwardAll the following statements about DNA are true, EXCEPT: O DNA is a double-helix, consisting of a sugar-phosphate backbone. O DNA is made up on nucleotides, which consist of one sugar, one phosphate, and one base. O DNA consists of 4 bases - adenine, uracil, cytosine, and guanine. The two main functions of DNA are to replicate itself and to create proteins (by providing the template for protein synthesis). O The sugar in DNA is deoxyribose.arrow_forwardImagine that DNA synthesis is occurring, and the left part of Figure 1 (marked ‘h’) is the product/daughter strand of this process. Which one of the following options identifies the position at which the next nucleotide be added? At the top of this part of the figure, marked ‘e’ At the bottom of this part of the figure, marked ‘f’ Both the top, marked ‘e’ and the bottom, marked ‘f’ Neither the top, marked ‘e’ nor the bottom, marked ‘f’arrow_forward
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