In chipmunks, the relationship between genotype and the age at which heart attacks occur is similar to that in squirrels. However, in chipmunks that are homozygous for the normal LDL receptor allele, Fn, only normal receptors are present. Heterozygous chipmunks have a single type of LDL receptor present on the cell surface, but those defective receptors exhibit only 50% of the normal LDL binding capacity. Finally, chipmunks that are homozygous for the defective receptor allele possess receptors with virtually no LDL binding ability. NAME and DEFINE the genetic phenomenon illustrated here.

which of the following statements are false? Drugs such as Ataluren should be effective in treating all types of Pax6 mutations Gene therapy stategies aimed at over production of Pax6 should be an effective strategy for Aniridia treatment The target protector strategy developed by the Howard lab for Aniridia treatment is aimed at increasing the expression of the mutant allele of Pax6 all of the above none of the above

1. ALT is not used as a hepatocellular damage marker in cattle. Explain why.

In Labrador retrievers fur color is controlled by two genes. One gene controls pigment production with the dominant B allele producing a black pigmentation and the recessive b allele a brown pigmentation. The other gene controls the deposition of the pigment in the hair with the dominant E allele producing a functional transport system and the recessive e allele a nonfunctional transport system. Which of the following genotypes belongs to a true-breeding brown lab, i.e. a lab that produces nothing but brown offspring when bred with another lab of the same genotype?   Choose an answer below: B/b, e/e b/b, E/e b/b, e/e B/B, e/e none of the above

The E132:GAL4 construct engineered into a fruit fly will cause