Which of the following events is not associated with the establishment of allelic exclusion of immunoglobulin heavychain loci? a. active transcription of RAG1 and RAG2 b. degradation of RAG proteins c. expression of only one productively rearranged heavychain locus d. remodeling of chromatin structure of heavy-chain locus so that it resists gene rearrangement e. formation of a functional pre-B-cell receptor.

Q: The normal function of the Rb protein is toa. act as a brake on cell division.b. produce…

A: BASIC INFORMATION  CELL DIVISION  It is necessary for all the cells In this the parent cell divides…

Q: Which of the following statements about innate lymphoid cells is true? (ONE ANSWER)   Require the…

A: Innate lymphoid cells (ILCs) are immune cells that lack a specific antigen receptor but can produce…

Q: Suppose you discover a drug that has potential antiviral effect against SARS-CoV2 so you tested its…

A: In microarray, the cDNA of both treated and untreated cells well put together in a well for a…

Q: A 25-year old man is concerned about his fmaily history of ankylosing spondylitis. He has not yet…

A: Ankylosing spondylitis is a condition where prolonged inflammation can lead to the fusion of bones…

Q: 28. The molecules mediating signal transduction on a B-cell following antigen binding to BCR are…

A: B cell It is a type of lymphocyte which is involved in providing the humoral immunity component of…

Q: Developing B cells that fail to make productive D to J heavy-chain rearrangements on both homologous…

A: B cells get matured in the bone marrow or in the lymph node. Mature B cells express antibodies on…

Q: Which of the following might explain why some individuals lack the ability to make enough T-cells?…

A: T-cells are generally one kind of lymphocyte and one of the crucial parts of white blood cells.…

Q: Which ONE of these is TRUE regarding the aetiology of acute lymphoblastic leukaemia (ALL)? Select…

A: in regarding of the aetiology of Acute Lymphoblastic Leukemia (ALL)

Q: Are p granules morphogens? If not, What distinguishes them from BMP and other morphogens?

A: Morphogens are characterized as locally generated signaling molecules which operate and spread over…

Q: Any given MHC molecule binds peptides that are related structurally. These families of peptides have…

A: MHC MHC is the Major Histocompatibility Complex that consists of genes that encode specialised…

Q: Which of the following can be answered by immunohistochemistry? Select all that apply. a. Whether…

A: Few important points : Immunohistochemistry is basically a localization of known antigen in tissue…

Q: Select one or more: a. Maternal IgG transferred across the placenta b. Maternal dimeric IgA…

A: Antibodies are specific proteins that are synthesized in the body when exposed to antigens.In the…

Q: Briefly, what are the 2 ‘checkpoints’ in development for the B cell? When do the B cells pause to…

A: In humans, B-cells are a type of WBCs (white blood cells) involved in the humoral immunity…

Q: Describé combination in develőpment ôf cell. Inclüde in your description the roles of RSS, RAG-1 and…

A: Answer :: Recombination activating gene (RAG) products are required for the rearrangement of antigen…

Q: A number of minor cancerous cells and infected viruses, such as Epstein Barr (EBV), are able to go…

A: Cytotoxic T cells or cytotoxic T lymphocytes are the type of T lymphocytes that plays a role in…

Q: graduate student wants to isolate cells from a patient and grow them perpetually in culture to study…

A: The correct answers are as follows- A. Telomerase C. MDM2  A graduate student wants to isolate cells…

Q: Sequences of DNA that are in Signal Joint are responsible for recombination event in somatic cells…

A: The group of organs that protect the body from various pathogens constitute the immune system. They…

Q: Linked recognition is best described as _____. a. the delivery of the co-stimulatory signal by…

A: Humoral immunity involves the activation of lymphocytes (B and T lymphocytes) to provide defence…

Q: In regard to antigen presentation, MHC class I molecules usually present peptides derived from…

A: Introduction: T cell receptors (TCR) are present on T lymphocytes that are one of the immune cells…

Q: Ataxia-telangiectasis (ATM) is a rare genetic neurodegenerative disease. About 20% of people with…

A: Ataxia-telangiectasia ( A-T) is caused by mutations in the ATM (ATM serine/threonine kinase or…

Q: The light-chain genes remain in the germline configuration. (Select all that apply.) Stem cell Early…

A: The V and J exons of an Ig light chain protein (Kappa or Lambda) encode the variable area, whereas…

Q: (a) Identify both the cellular component and the location of the component that is responsible for…

A: Luciferase reporter produces luminescence. If cells contain a luciferase vector, the luminescent…

Q: D. TH17 17. Down regulation of ..............allow naïve T cells to enter lymph nodes? B. B7 C.…

A: T cells These are white blood cells that belong to the adaptive immune system. These cells play a…

Q: At what stage of B cell development are autoreactive cells removed? A. stem cell stage B. pro-B…

A: These can be caused by pathogen or any other foreign agent. This function is carried out by the…

Q: During positive selection, if the selecting MHC molecule is class I, then a. gene expression of…

A: Positive selection refers to the event in which T cells become largely specified to develop…

Q: Genetic factors contribute to the development of IgE-mediated allergic disease.  Genetic studies…

A: In certain people, allergies can result in a variety of immunological responses. Both allergic…

Q: A metabolically stressed epithelial cell expresses the protein MICits surface and then interacts…

A: NK cells are activated as an early event during an immune response and does not require the need for…

Q: The adaptive immune system uses multiple strategies to generate diversity in our ability to mount…

A: Adaptive immunity is made up of two main components: T cells and B cells. An immune system that…

Q: Humans with defective expression of the integrin LFA-1 have an immunodeficiency disease…

A: Introduction : The ability of the body to defend against pathogens is referred to as immunity. It…

Q: Barriers to using pig organs in human transplantation are _____. (Select all that apply.) a. the…

A: Graft rejection is one of the major problems in xenotransplantation. It is important to understand…

Q: Which of the following statements about Notch 1 is correct? (Select all that apply.) Select one or…

A: Concept used :  Notch 1 gene    Definitions required -  Notch 1 gene :  Notch one is a gene that…

Q: Match the gene on the left with the gene category on the right.…

A: Genes  Genes are the information coded in a DNA. They make our protein and enzyme. They are…

Q: How would this illustration change if it showed class switching by B cells residing in Peyer’s…

A: Class Switching is a type of biological mechanism that converts the production of a B-cell's…

Q: In B cells, what mechanism ensures that only rearranged V genes are transcribed?

A: A gene (from genos (Greek) which means generation or birth or sex) is a basic unit of heredity and a…

Q: Wearing a face mask, hand hygiene, and social distance); all of these are ways to break the chain of…

A: Since you have asked multiple questions, we will solve the first question for you. If you want any…

Q: The phenomenon of allelic exclusion ensures that B cells a. use only one V, D, and J segment…

A: The antibody is generally called immunoglobin that is present as a Y-shaped protein and is involved…

Q: Which ONE of the following genetic patterns defines a patient with acute myeloid leukaemia with the…

A: Any kind of alteration in the nucleotide sequence of an organism’s genome is referred to as a…

Q: Humanized monoclonal antibodies are best described as a. antibodies made in mice in which the…

A: Ans: The antibodies generated in the laboratory that specifically binds to single epitope or antigen…

Q: Amino acid variation among MHC class II allotypes that present antigens to CD4 T cells is…

A: MHC or major histocompatibility complex is a set of genes. These genes are responsible for the…

Q: Which of the following is true about MHC? Check all that apply.   A. MHC I is expressed in all…

A: Major Histocompatibility Complex(MHC) is basically a group of genes on DNA.It mainly helps the…

Q: shows the directed migration of two immune cell types, neutrophils (red) and macrophages (green) to…

A: Immune cells are the sort of cells that emerge from stem cells in the bone marrow and mature into…

Q: Which of the following statements best explains why the immune system can continue to make…

A: Rituximab is a medication that will be mostly used for treating rheumatoid arthritis as well as…

Q: The MHC molecule diversity is generated by which of the following mechanisms? Select one: a. Somatic…

A: Introduction :- A sizable region of vertebrate DNA called the major histocompatibility complex…

Q: Order the listed proteins in the correct order so that cell proliferation is activated as the…

A: HGF stimulates epithelial cell proliferation, motility, morphogenesis via tyrosine phosphorylation.…

Q: Which of the following is NOT true of ITAMs?   a. They are attached to the tails of the Ig   b.…

A: Introduction: ITAMs (immunoreceptor tyrosine-based activation motifs) are retained four aminoacid…

Q: What marker proteins does BRCA1 directly and indirectly interact with ? Is RAD51 and p53 a marker…

A: The genes BRCA1 and BRCA2 (BReast CAncer genes 1 and 2, respectively) generate proteins that aid in…

Q: fill in the blank for the following:  a. HPAT2,3, and 5 when prevented from being transcribed…

A: Nucleic acids are biological molecules "Proteins required for the construction and function of all…