Which of the following events is not associated with the establishment of allelic exclusion of immunoglobulin heavychain loci? a. active transcription of RAG1 and RAG2 b. degradation of RAG proteins c. expression of only one productively rearranged heavychain locus d. remodeling of chromatin structure of heavy-chain locus so that it resists gene rearrangement e. formation of a functional pre-B-cell receptor.

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